Alternative treatment for retinoblastoma: Intra-arterial chemotherapy with melphalan.

Case Report: A 10-month old infant was referred for the study of a leukocoria of the left eye of one month onset. On examination, a retinoblastoma occupying the macular area was detected. Treatment with intra-arterial chemotherapy (melphalan 6 mg) was performed, with no further intervention required for disease control.

[Necrobiotic xanthogranuloma. Differential diagnosis, treatment and systemic involvement. Case report].

Case Report: A 48-year-old male was referred to our hospital for further evaluation of eyelid edema with bilateral yellowish ulcerated nodules. Suspecting a xanthogranulomatosis, imaging tests and biopsy were performed with diagnosis of necrobiotic xanthogranuloma. IgG monoclonal gammapathy was diagnosed in a systemic study.

Analysis of factors that determine the diagnostic yield of temporal artery biopsy.

Purpose: To analyse the diagnostic yield of temporal artery biopsy in the diagnosis of giant cell arteritis, and to correlate these results with the clinical and laboratory features which indicate it, in an attempt to increase the efficiency of this technique and try to "save biopsies".

Methods: A retrospective cohort study including suspected giant cell arteritis cases in which a temporal artery biopsy was performed. The data recorded included demographic, clinical and laboratory information.

[Atypical ophthalmic findings in Susac syndrome].

Case Report: A 25-year-old woman with encephalopathy and sensorineural hearing loss was referred to us in order to confirm Susac syndrome, due to bilateral visual loss. Funduscopic examination revealed peripheral retinal microangiopathy.

Discussion: Susac syndrome is typically characterized by the clinical triad of encephalopathy, branch retinal artery occlusions, and hearing loss.

[Chronic ethanol feeding induces oxidative stress in the optic nerve of rats].

Purpose: To assess the involvement of oxidative stress in optic nerves after chronic intake of ethanol in adult rats, when compared to animals fed with an ethanol-free isocaloric diet.

Methods: Male Sprague-Dawley rats were used throughout the study. They were fed an ethanol-containing liquid diet, whereas the pair-fed group was given an ethanol-free isocaloric diet.