Publications by authors named "J Aspa"
Introduction: Peripheral blood mononuclear cells (PBMCs) trafficking is regulated by chemokines, which modulate leukocyte migration toward tumors and may collaborate in the efficacy of immunotherapy. In our study, we investigated whether the CXCL12/CXCR4 axis plays a role in the efficacy of immunotherapy in non-small cell lung cancer (NSCLC) by analyzing CXCR4 expression for CXCR4 in peripheral blood (PB), and the expression of its ligand CXCL12 in tumor.
Methods: We identified PBMCs expressing CXCR4 using flow cytometry in a prospective cohort of NSCLC patients before starting anti-PD-1 immunotherapy.
Background: Community-acquired pneumonia (CAP) is associated with high morbidity and hospitalization rate. In infectious diseases, host genetics plays a critical role in susceptibility and immune response, and the immune pathways involved are highly dependent on the microorganism and its route of infection. Here we aimed to identify genetic risk loci for CAP using a case-control genome-wide association study (GWAS).
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- - Long-COVID (LC) is defined by lingering symptoms for over 3 months post-COVID-19 infection, potentially caused by immune system dysregulation and chronic inflammation.
- - The study identifies specific CD4 T cell subpopulations in COVID-19 recovery and reveals that certain CCR6-expressing T cells are reduced in LC patients, while others increase.
- - LC patients demonstrate lower levels of IFN-γ-secreting CD8 T cells when exposed to the SARS-CoV-2 Spike protein, highlighting the importance of CCR6 in understanding LC's underlying mechanisms.
Article Synopsis
- The study investigates the connection between SARS-CoV-2 viral load (viremia) and genetic variations (SNPs) linked to the severity of COVID-19 in a group of hospitalized patients at University Hospital La Princesa.
- Out of 340 patients analyzed, only 37.1% had positive viremia, with specific SNPs (like rs2071746 and rs78958998) associated with a higher risk of viremia, while others (like rs11052877 and rs33980500) were linked to a lower risk.
- The findings suggest that certain genetic variants contribute to differences in SARS-CoV-2 viremia among individuals, highlighting the
Article Synopsis
- The study investigates whether excess weight can predict the effectiveness of immune checkpoint inhibitors in patients with advanced non-small cell lung cancer.
- An analysis of 79 patients showed that those with excess weight had a significantly better response to immunotherapy compared to those without, achieving higher response rates and longer progression-free and overall survival.
- The findings indicate that excess weight could serve as a potential biomarker for better outcomes in patients receiving anti-PD-1 treatments specifically, highlighting the differential impact based on treatment type.