Diesel Particulate Matter (DPM)-Induced Metabolic Disruption in Mice Is Mitigated by Sodium Copper Chlorophyllin (SCC).

Background/objectives: The increasing prevalence of metabolic disorders underscores the need for effective interventions to mitigate environmental stressors such as diesel particulate matter (DPM), a major urban air pollutant. DPM is composed of fine carbonaceous particles that can induce systemic inflammation. This phenomenon results in metabolic dysfunction such as adipocyte hypertrophy, insulin resistance, and mitochondrial impairment in body tissues.

The Incretin Effect of Yerba Maté () Is Partially Dependent on Gut-Mediated Metabolism of Ferulic Acid.

Background/objectives: Yerba maté (YM), a traditional herbal beverage made from , contains bioactive compounds like polyphenols and alkaloids known for their metabolic benefits. This study investigates YM's incretin effects, focusing on glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP). : Male and female C57BL/6 mice were supplemented with YM for four weeks.

Transcriptomic Insights into Gas6-Induced Placental Dysfunction: Gene Targets for Preeclampsia Therapy.

Preeclampsia (PE) is a complex pregnancy-specific disorder characterized by hypertension, proteinuria, and systemic inflammation, posing significant risks to maternal and fetal health. This study investigates the role of growth arrest-specific protein 6 (Gas6) in PE pathogenesis using a rat model. Gas6 administration induces hallmark PE features, including hypertension, proteinuria, and significant alterations in placental gene expression.

Predicting and optimising outcome for biliary atresia.

Biliary atresia (BA) remains a disease of significant morbidity and mortality world-wide. Early and accurate diagnosis facilitates early intervention and improves outcomes. The gold standard in diagnosing BA is a liver biopsy followed by cholangiography, usually performed intra-operatively.

Enhancing digestion and gut fermentation in pigs: evaluation of the effects of reconstituted and ensiled sorghum grains.

The effect of ensiling sorghum grains harvested at different dates on pig nutrient digestibility and fermentability was evaluated using approaches. A sorghum crop was divided following a randomised complete block design and distributed in 3 treatments: 1) grain harvested 113 d after sowing (40% moisture) and ensiled for 180 d (high moisture, HMG), 2) grain harvested 159 d after sowing (15% moisture), rehydrated to 40% moisture and ensiled for 180 d (reconstituted, REC), and 3) sorghum grain harvested 159 d after sowing (15% moisture) and stored dry (dry, DG). Starch content was lower in ensiled grains (HMG and REC) ( = 0.