Publications by authors named "J Aron-Wisnewsky"
Background & Aims: Sarcopenic obesity (SO) is associated with cardiometabolic disorders and steatotic liver disease and carries major health risks. We assessed the hepatic and metabolic clinical phenotype associated with SO in patients with obesity undergoing bariatric surgery (BS). We also evaluated whether weight-loss and metabolic improvement post-surgery differ between patients with and without SO.
View Article and Find Full Text PDFImidazole Propionate (ImP), a gut-derived metabolite from histidine, affects insulin signaling in mice and is elevated in type 2 diabetes (T2D). However, the source of histidine and the role of the gut microbiota remain unclear. We conducted an intervention study in mice and humans, comparing ImP kinetics in mice on a high-fat diet with varying histidine levels and antibiotics, and assessed ImP levels in healthy and T2D subjects with histidine supplementation.
View Article and Find Full Text PDFArticle Synopsis
- Obstructive sleep apnea (OSA) impacts nearly 1 billion people globally, causing chronic intermittent hypoxia (CIH) that leads to organ damage, especially affecting the heart and visceral white adipose tissue (WAT).
- The study aimed to explore if CIH causes premature senescence in visceral WAT, which in turn may trigger changes in heart structure and function.
- Results showed that CIH caused significant changes in WAT and early signs of heart damage, but these effects could be mitigated through surgical removal of fat tissue or deletion of specific genes, highlighting visceral WAT senescence as a promising target for combating OSA-related issues.
The epicardial adipose tissue confined in the atrioventricular groove can be used to assess atrial adipose tissue and atrial dysfunction in cardiac magnetic resonance imaging.
Eur Heart J Imaging Methods Pract
January 2024
Aims: The growing interest in epicardial adipose tissue (EAT) as a biomarker of atrial fibrillation is limited by the difficulties in isolating EAT from other paracardial adipose tissues. We tested the feasibility and value of measuring the pure EAT contained in the atrioventricular groove (GEAT) using cardiovascular magnetic resonance (CMR) imaging in patients with distinct metabolic disorders.
Methods And Results: CMR was performed on 100 patients from the MetaCardis cohort: obese ( = 18), metabolic syndrome (MSD) ( = 25), type-2 diabetes (T2D) ( = 42), and age- and gender-matched healthy controls ( = 15).