Competition shapes the landscape of X-chromosome-linked genetic diversity.

X chromosome inactivation (XCI) generates clonal heterogeneity within XX individuals. Combined with sequence variation between human X chromosomes, XCI gives rise to intra-individual clonal diversity, whereby two sets of clones express mutually exclusive sequence variants present on one or the other X chromosome. Here we ask whether such clones merely co-exist or potentially interact with each other to modulate the contribution of X-linked diversity to organismal development.

Maintenance of angiogenesis inhibition with aflibercept after progression to bevacizumab in metastatic colorectal cancer: real life study in the Valencian community.

Introduction: The second-line chemotherapy in metastatic colorectal cancer (mCRC) with FOLFIRI-aflibercept demonstrated an increase in survival compared with FOLFIRI in patients previously treated with oxaliplatin-based regimens. Few data are available in patients treated previously with bevacizumab. Our objective is to evaluate the efficacy and safety of FOLFIRI-aflibercept in second-line treatment in patients who have previously received bevacizumab.

Safety and efficacy of sorafenib in the treatment of advanced hepatocellular carcinoma: a single center experience.

Sorafenib is the standard treatment of patients with advanced hepatocellular carcinoma (HCC), with demonstrated outcome benefits in randomized clinical trials. We present a single-center experience with sorafenib with the aim to establish its efficacy and safety in daily clinical practice. A total of 62 patients were treated with sorafenib 400 mg/12 h until disease progression or unacceptable toxicity.

[Prevalence of nosocomial infection in Navarre. Aggregated data of the EPINE study for 2005].

Nosocomial infection is a serious problem of morbidity and mortality that, according to the 2003 national prevalence data affected 6,5-7% of all the patients admitted in Spanish hospitals. Our aim is to assess the prevalence of nosocomial infection in Navarre, from the aggregated data of each participant in the EPINE (Study of Prevalence of Nosocomial Infection in Spain) in 2005, and to analyse different features of the nosocomial infections to compare them with the global data for Spain. The prevalence of patients with nosocomial infection was 5,6% and the prevalence of patients with community infection was 13,2%.

Outbreak of gastric mucormycosis associated with the use of wooden tongue depressors in critically ill patients.

Objective: To describe a nosocomial outbreak of gastric mucormycosis caused by Rhizopus microsporus var. rhizopodiformis in five adult patients admitted to an intensive care unit (ICU).

Design: Epidemiological surveillance study.