Publications by authors named "J Anzai"
Background: The multi-day Boston Remote Assessment of Neurocognitive Health (BRANCH) is a remote, web-based assessment designed to capture the earliest cognitive changes in the preclinical stage of Alzheimer's disease (AD). It has been validated in unimpaired older adults, but as individuals progress on the AD continuum, assessments need to remain feasible and valid at different clinical stages. The focus of this study was to assess feasibility and validity of multi-day BRANCH in participants with and without cognitive impairment.
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- The study investigates how the monoclonal antibody lecanemab, used for treating Alzheimer's by targeting amyloid beta, interacts with plasma proteins, particularly focusing on its relatively short half-life due to these interactions.
- * Researchers employed techniques like ELISA and western blotting to analyze the binding of a lecanemab biosimilar to plasma proteins, identifying fibrinogen as a potential binding partner.
- * The findings suggest that fibrinogen levels could affect the availability of lecanemab in the bloodstream, highlighting the importance of considering plasma protein binding in the clinical use of therapeutic antibodies for neurodegenerative diseases.
Article Synopsis
- Lecanemab is a monoclonal antibody designed to target amyloid beta in Alzheimer's disease, with its short half-life influenced by plasma protein interactions.
- The study investigated how lecanemab binds to plasma proteins, with a focus on its biosimilar, using techniques like ELISA and Western blotting.
- Results showed that fibrinogen is a binding partner for lecanemab, potentially affecting the availability of free antibodies in the bloodstream and highlighting the importance of plasma protein binding in therapeutic antibody treatment for neurodegenerative diseases.
Introduction: There has been an increasing desire for the development of predictive periodontal regenerative therapy for severe periodontitis. In this study, we investigated the effect of the combined use of fibroblast growth factor-2 (FGF-2), a drug for periodontal regeneration approved in Japan, and carbonated apatite (COAp), bioresorbable and osteoconductive scaffold, on periodontal regeneration in beagle dog model of one-wall periodontal defect (severe intraosseous defect) for 24 weeks in comparison with COAp or vehicle alone.
Methods: One-wall periodontal defects were created (mesiodistal width × depth: 4 × 4 mm) on the mesial portion of the mandibular first molar (M1) of beagle dogs on both side.
Subjective cognitive decline (SCD), which precedes Mild Cognitive Impairment and dementia, may be affected by purpose in life (PiL) and loneliness in older adults. We investigated associations among PiL, loneliness, and SCD in US Latino ( = 126), Black ( = 74), Asian ( = 33), and White ( = 637) adults. Higher PiL predicted lower SCD in all groups (p-values < .
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