Retinocytoma/retinoma: comparative analysis of clinical features in 78 tumors and rate of transformation into retinoblastoma over 20 years.

Purpose: To explore clinical features and long-term outcomes in patients with retinocytoma/retinoma.

Methods: The medical records of patients with retinocytoma/retinoma over a 20-year period were reviewed retrospectively to compare patient age at presentation (<4 vs ≥4 years), tumor type, and tumor focality (unifocal vs multifocal).

Results: Of 2,021 patients with retinoblastoma, 62 (3%; median age, 5 years; 85% white; 58% male) had 78 tumors: 54 retinocytoma (69%) and 24 retinoma (31%).

Adenoma and Adenocarcinoma of the Retinal Pigment Epithelium: A Review of 51 Consecutive Patients.

Purpose: To describe the clinical and imaging characteristics, pathologic features, and management options of retinal pigment epithelium (RPE) adenoma/adenocarcinoma.

Design: Retrospective case series.

Participants: Fifty-one patients with RPE adenoma/adenocarcinoma.

Choroidal Melanoma Simulating Adenoma of the Retinal Pigment Epithelium Arising at the Site of Congenital Hypertrophy of the Retinal Pigment Epithelium.

Neoplasms of the retinal pigment epithelium (RPE) are rare tumors that can simulate choroidal melanoma, but clinical and imaging characteristics often differentiate these lesions. We report a 70-year-old male with an abruptly elevated pigmented lesion that arose at the site of congenital hypertrophy of the RPE and demonstrated associated exudation, as well as feeding and draining vessels, suggestive of RPE adenoma. Optical coherence tomography showed retinal elevation with serous retinal detachment adjacent to the mass, and ultrasonography revealed an abruptly elevated, moderately echodense mass of 6.

Choroidal Ischemia Sparing the Watershed Zone following Intra-Arterial Chemotherapy for Retinoblastoma.

Purpose: Intra-arterial chemotherapy (IAC) has become a mainstay in the management of retinoblastoma, especially in advanced or refractory disease. However, IAC is not without complications, and chemotherapy toxic effects can lead to partial or complete choroidal ischemia, often causing vision loss.

Methods: This is a case report.

Primary Intra-Arterial Chemotherapy for Retinoblastoma in the Intravitreal Chemotherapy Era: Five Years of Experience.

Purpose: To report our 5-year experience with intra-arterial chemotherapy (IAC) in the intravitreal chemotherapy (IvitC) era.

Methods: Retrospective review of retinoblastoma treated with primary unilateral IAC in the IvitC era (2012-2017).

Results: There were 34 eyes treated with IAC alone versus 20 eyes treated with IAC plus IvitC for vitreous seeds.