Publications by authors named "J Antel"
Article Synopsis
- Recent studies suggest that oligodendrocyte lineage cells show varying functional and molecular characteristics during development and in diseases, notably multiple sclerosis, where grey matter lesions undergo more remyelination than white matter lesions.* -
- Research comparing progenitor cells and mature oligodendrocytes from grey and white matter revealed that grey matter cells were better at ensheathing synthetic nanofibers and were more vulnerable to metabolic injury, indicating unique molecular profiles between the two types.* -
- RNA sequencing demonstrated that differences in gene expression are more pronounced between cell types than regions, with grey matter cells showing higher levels of genes important for myelination, while both cell types exhibited up-regulated genes related to stress and injury response.*
Article Synopsis
- Inflammation may play a significant role in epilepsy, especially in patients with multiple sclerosis (MS), who have higher seizure rates than the general population.
- This study analyzed data from the FDA Adverse Event Reporting System to investigate the connections between MS treatments and the occurrence of epilepsy.
- Results indicated that certain medications, particularly ibrutinib, showed an inverse association with epilepsy occurrences, suggesting they could be explored for new treatment options for epilepsy.
Mature myelinating oligodendrocytes, the cells that produce the myelin sheath that insulates axons in the central nervous system, have distinct energetic and metabolic requirements compared to neurons. Neurons require substantial energy to execute action potentials, while the energy needs of oligodendrocytes are directed toward building the lipid-rich components of myelin and supporting neuronal metabolism by transferring glycolytic products to axons as additional fuel. The utilization of energy metabolites in the brain parenchyma is tightly regulated to meet the needs of different cell types.
View Article and Find Full Text PDFObjective: Post-operative development of restrictive eating disorders can occur in patients after bariatric surgery. In children and adolescents with anorexia nervosa (AN) or atypical AN, premorbid body mass index (BMI) has recently been shown to predict total weight loss. We hypothesized that pre-operative BMI similarly predicts weight loss and the development of a restrictive eating disorder in adult bariatric patients.
View Article and Find Full Text PDFMature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous system. Recent evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to axons. Despite the recognition of potential heterogeneity in mature oligodendrocyte function, a comprehensive summary of mature oligodendrocyte diversity is lacking.
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