Publications by authors named "J Andrew Widmer"
Cyanobacteria and their toxins can have multiple effects on agricultural productivity and water bodies. Cyanotoxins can be transported to nearby crops and fields during irrigation and may pose a risk to animal health through water sources. Spatial and temporal variations in cyanotoxin concentrations have been reported for large freshwater sources such as lakes and reservoirs, but there are fewer studies on smaller agricultural surface water bodies.
View Article and Find Full Text PDFA new sensing paradigm for the vibroacoustic detection of pedicle screw loosening.
Med Biol Eng Comput
November 2024
Article Synopsis
- The current method for assessing pedicle screw loosening relies heavily on radiation-emitting imaging, which can be unreliable in certain cases.
- The authors propose a new, radiation-free technique using vibroacoustic sensing that involves exciting the vertebrae with vibrations and measuring them with a sensitive sensor attached to the screw.
- The new method has been validated through simulations and physical tests on cadaveric lumbar spine specimens, achieving high sensitivity and specificity in detecting loose implants.
Most processes of life are the result of polyvalent interactions between macromolecules, often of heterogeneous types and sizes. Frequently, the times associated with these interactions are prohibitively long for interrogation using atomistic simulations. Here, we study the recognition of N6-methylated adenine (mA) in RNA by the reader domain YTHDC1, a prototypical, cognate pair that challenges simulations through its composition and required timescales.
View Article and Find Full Text PDFArticle Synopsis
- Metabolic-bariatric surgery (MBS) is the best treatment for obesity, but many patients experience recurrent weight gain after Roux-en-Y gastric bypass (RYGB), leading to associated health issues; gastric pouch resizing (GPR) offers a low-risk solution for this weight regain.
- A study involving 48 patients who underwent GPR after RYGB showed significant weight stabilization over time, with a mean follow-up indicating an improvement in BMI and resolution of obesity-related health conditions in more than half of the participants.
- The procedure was determined to be safe, with low rates of complications, and patients reported high satisfaction levels, making GPR a worthwhile option for those struggling with weight regain post-surgery.
Article Synopsis
- * A deep learning pipeline was developed, utilizing 555 manually annotated bi-planar radiographs, focusing on segmenting vertebral bodies and pelvic landmarks through a trained U-Net architecture.
- * The pipeline showed promising results, achieving a 61% success rate in predicting Cobb angles and maintaining high agreement with expert measurements, indicating its potential for effective spinal analysis.