Salmon-IgM Functionalized-PLGA Nanosystem for Florfenicol Delivery as an Antimicrobial Strategy against .

Salmonid rickettsial septicemia (SRS), caused by , has been the most severe health concern for the Chilean salmon industry. The efforts to control infections have focused on using antibiotics and vaccines. However, infected salmonids exhibit limited responses to the treatments.

KLF17 is an important regulatory component of the transcriptomic response of Atlantic salmon macrophages to infection.

is the most important health problem facing Chilean Aquaculture. Previous reports suggest that can survive in salmonid macrophages by interfering with the host immune response. However, the relevant aspects of the molecular pathogenesis of have been poorly characterized.

Phylogenomic analysis of the duo: approaches to the origin of periodontitis.

is an oral human pathogen associated with the onset and progression of periodontitis, a chronic immune-inflammatory disease characterized by the destruction of the teeth-supporting tissue. belongs to the genus which is characterized by being composed of Gram-negative, asaccharolytic, non-spore-forming, non-motile, obligatory anaerobic species, inhabiting niches such as the oral cavity, urogenital tract, gastrointestinal tract and infected wound from different mammals including humans. Among the genus, stands out for its specificity in colonizing the human oral cavity and its keystone pathogen role in periodontitis pathogenesis.

Non-Specific Antibodies Induce Lysosomal Activation in Atlantic Salmon Macrophages Infected by .

, an aggressive intracellular pathogen, is the etiological agent of salmonid rickettsial septicemia (SRS). This is a chronic multisystemic disease that generates high mortalities and large losses in Chilean salmon farming, threatening the sustainability of the salmon industry. Previous reports suggest that is able to survive and replicate in salmonid macrophages, inducing an anti-inflammatory environment and a limited lysosomal response that may be associated with host immune evasion mechanisms favoring bacterial survival.

Understanding gold toxicity in aerobically-grown Escherichia coli.

Background: There is an emerging field to put into practice new strategies for developing molecules with antimicrobial properties. In this line, several metals and metalloids are currently being used for these purposes, although their cellular effect(s) or target(s) in a particular organism are still unknown. Here we aimed to investigate and analyze Au toxicity through a combination of biochemical and molecular approaches.