Biochemical and evolutionary interactions between mitochondrial and nuclear genomes ('mitonuclear interactions') are proposed to underpin fundamental aspects of biology including evolution of sexual reproduction, adaptation and speciation. We investigated the role of pre-mating isolation in maintaining functional mitonuclear interactions in wild populations bearing diverged, putatively co-adapted mitonuclear genotypes. Two lineages of eastern yellow robin Eopsaltria australis-putatively climate-adapted to 'inland' and 'coastal' climates-differ by ~7% of mitogenome nucleotides, whereas nuclear genome differences are concentrated into a sex-linked region enriched with mitochondrial functions.
View Article and Find Full Text PDFCreutzfeldt-Jakob disease (CJD) is a rare neurodegenerative condition. This report presents the largest published case series on the condition. The palliative care symptom burden and management of these patients is considered.
View Article and Find Full Text PDFLessons learned, methodologies, and application of tools that have been developed within the context of research on the environmental impacts, health, and safety of nanomaterials (nano-EHS) provide a solid foundation for research on nano/microplastics. In this communication, we summarize key discoveries obtained through major research efforts over the last two decades in the area of nano-EHS that are applicable for the study of micro- and nano-plastics (referred to here more generally as particulate plastics). We focus on how non-equilibrium particle transport processes affect: 1) bio-physico-chemical mechanisms of particle toxicity and determining dose-response relationships; 2) the potential for biouptake, bioaccumulation, translocation, trophic transfer and intergenerational effects of particulate contaminants; 3) extrapolations from laboratory experiments to complex systems and the impact of environmental transformations; 4) the formulation of functional assays as a basis for predicting the impacts of particulate contaminants in complex environments; 5) the relative importance of incidental particles compared with engineered particles and, 6) experience with data platforms, curation, and experimental design.
View Article and Find Full Text PDFAustralia's 2019/20 bushfire season was one of the most severe on record, from both land mass burned and the economic impact. This extreme weather season allowed the researchers to examine the effect of high PM exposure during high bushfire days on birthweight and gestational age. It is well known that bushfire smoke is harmful to human health.
View Article and Find Full Text PDFRefugees and asylum seekers might have an increased risk of antimicrobial resistance (AMR) carriage or infection due to several factors, with conflict and war known to accelerate the spread of AMR. However, data are scarce on prevalence and risk factors for AMR among refugees and asylum seekers and how they are affected globally; in addition, how their risk compares to that of the host-country population is unclear. We aimed to explore and assess global AMR data among refugees and asylum seekers.
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