Bacteriocins (meningocins) in Norwegian isolates of Neisseria meningitidis: possible role in the course of a meningococcal epidemic.

In the Neisseria meningitidis strain MC58 (serogroup B; ET-5 complex) genome three putative islands of horizontally transferred DNA (IHTs) have been identified. IHT-A2 codes for eight hypothetical proteins and two disrupted open reading frames with similarity to a secretion protein (NMB0097) and an ABC transporter (NMB0098). The strains MC58 and 44/76 (shown here) are meningocin resistant/weakly sensitive.

Unusual antineisserial activity expressed by a systemic isolate of Neisseria meningitidis. antimeningococcal effect and properties.

Antineisserial activity expressed by the systemic Neisseria meningitidis strain 77/79A was studied using the cross-streaking technique. Of 271 meningococcal isolates tested, > 84% were sensitive to this strain. The degree of susceptibility was largely dependent upon the agent characteristics of the individual isolates.

Production, isolation and purification of bacteriocins expressed by two strains of Neisseria meningitidis.

The systemic Neisseria meningitidis strain P241 and the healthy pharyngeal carrier strain BT878 produce bacteriocin-like substances during growth. A method has been devised for obtaining the active substances in solution. The activity was recovered by freeze-thaw extraction of dialyzed Todd-Hewitt agar medium into which the bacteriocins had diffused during growth of the producer strains.

Bacteriocins in Neisseria meningitidis. Screening of systemic patient strains and pharyngeal isolates from healthy carriers.

Systemic meningococcal isolates and meningococci from healthy pharyngeal carriers in Norway were screened for production of growth antagonistic substances. Seven (4.9%) of a total of 142 systemic strains and 3 (2.

Activity of bacteriocin-like agents from Neisseria meningitidis on strains isolated from patients and carriers.

Strains of Neisseria meningitidis isolated from patients were more often completely insensitive to five bacteriocin-like agents than carrier strains, but no particular bacteriocin type could be associated with patient strains. Two genetically distinct types of insensitivity could be separated by transformation. Insensitivity to four bactericidal agents (from the strains P201, P213, P241 and 99/79) was caused by one common genetic marker whereas insensitivity to a bacteriostatic agent (from the strain 77/79) was caused by another.