The Wade Programme in surgical anatomy: educational approach and 10-year review.

Background: Against a background of significant changes in UK medical education at both undergraduate and postgraduate levels, the Royal College of Surgeons of Edinburgh (RCSEd) established the Wade Programme in Surgical Anatomy in 2012, as a means of supporting the study of surgical anatomy throughout training. This article provides a 10-year review of the Wade Programme and its educational foundation.

Methods: A novel methodology, the 'Wade Educational Approach', was used in the design and development of a portfolio of professional courses at three training levels: Level 1 - RCSEd Affiliate, Level 2 - Early Years (MRCS) and Level 3 - Later Years (FRCS and CPD).

Poor response of HER2-positive mucinous carcinomas of breast to neoadjuvant HER2-targeted therapy: A study of four cases.

Background: Breast mucinous carcinoma (MC) is typically positive for estrogen receptor (ER) and progesterone receptor (PR) expressions and negative for human epidermal growth factor receptor (HER2) overexpression. HER2 positive MC is a rare entity; its response to neoadjuvant HER2-targeted therapy remains unclear.

Methods: Four cases of HER2 positive MC and seven cases of HER2 positive invasive ductal carcinoma with mucinous features (MCF) were identified.

Assessing horizontal gene transfer in the rhizosphere of using fabricated ecosystems (EcoFABs).

Horizontal gene transfer (HGT) is a major process by which genes are transferred between microbes in the rhizosphere. However, examining HGT remains challenging due to the complexity of mimicking conditions within the rhizosphere. Fabricated ecosystems (EcoFABs) have been used to investigate several complex processes in plant-associated environments.

Engineered reduction of S-adenosylmethionine alters lignin in sorghum.

Background: Lignin is an aromatic polymer deposited in secondary cell walls of higher plants to provide strength, rigidity, and hydrophobicity to vascular tissues. Due to its interconnections with cell wall polysaccharides, lignin plays important roles during plant growth and defense, but also has a negative impact on industrial processes aimed at obtaining monosaccharides from plant biomass. Engineering lignin offers a solution to this issue.