Publications by authors named "J Alegre-Diaz"
Background: There is limited population-based evidence on the prevalence of cognitive impairment in Mexico, a country with a rapidly aging population and where key risk factors, such as diabetes and obesity, are common. This study describes the distribution of cognitive impairment in adults from Mexico City.
Methods: This cross-sectional population-based study included participants from the Mexico City Prospective Study which recruited 150,000 adults aged ≥ 35 years in 1998-2004.
Background: Alcohol consumption is a leading cause of premature death globally, but there is no large-scale prospective evidence from Mexico.
Methods: The Mexico City Prospective Study recruited 150 000 adults aged 35 years or older between 1998 and 2004. Participants were followed up until Oct 1, 2022 for cause-specific mortality.
Objective: Evidence from low- and middle-income countries regarding the effect of smoking in people with diabetes is lacking. Here, we report the association of smoking with mortality in a large cohort of Mexican adults with diabetes.
Methods: Participants with diabetes mellitus (self-reported diagnosis, use of antidiabetic medications or HbA1c ≥ 6.
Article Synopsis
- Researchers analyzed genetic data from nearly 1 million individuals to create a comprehensive catalogue of human protein-coding variations, shedding light on gene function and the frequency of rare coding variants.
- The study identified over 10 million missense and 1.1 million loss-of-function variants, discovering 1,751 novel genes with rare biallelic loss-of-function variants and 3,988 genes intolerant to these variants.
- They estimate that 3% of people carry a clinically significant genetic variant and provide public access to their data to enhance genetic interpretation and support precision medicine.