Publications by authors named "J Aldinger"
Background/objectives: Prenatal psychology studies show that stress, depression, and psychological stress during pregnancy can have a significant impact on maternal and fetal health and are highly prevalent. The aim of the study was to compare maternal and neonatal short-term outcomes in pregnant women* (the asterisk (*) is used at the appropriate places in this text to indicate that all genders are included) with a history of prenatal maternal psychological stress (PMPS) with those of pregnant women* not exposed to PMPS to determine differences and identify risk factors.
Methods: Statistical tests for differences and relative risks between the groups were carried out with the perinatal data of University Hospital Tübingen from 2022 using IBM SPSS.
Article Synopsis
- - The study aimed to evaluate a new mouse model with a humanized Toll-like receptor-4 (hTLR-4) to investigate nickel allergy by assessing how it affects skin sensitization in mice.
- - Mice with the hTLR-4 receptor were exposed to nickel sulfate and showed significantly higher immune responses, including increased lymph node cellularity and elevated levels of IgE and various cytokines compared to hTLR-4-negative mice.
- - Results indicate that the hTLR-4 mouse model is more susceptible to nickel sensitization, making it a promising tool for future research on nickel allergy and its mechanisms.
Article Synopsis
- The study aims to create a deep learning algorithm using MRI to quickly and accurately classify individuals into groups: normal subjects, and patients with dilated cardiomyopathy, hypertrophic cardiomyopathy, and ischemic heart disease.
- A total of 1,337 subjects were analyzed, employing advanced imaging techniques and extracting key cardiac features to train the algorithm, testing its effectiveness through various statistical methods and comparisons against expert evaluations.
- The model achieved high accuracy rates, particularly distinguishing normal subjects with an area under the curve (AUC) of 0.952, while improving classification metrics slightly with the addition of unlabeled normal data.
Accelerated chronic lymphocytic leukemia/small lymphocytic lymphoma (A-CLL/SLL) is a histologically aggressive subtype of CLL/SLL that lies in between conventional CLL/SLL (C-CLL/SLL) and Richter transformation (RT) on the biological spectrum. Although the histologic criteria for A-CLL/SLL were defined 14 years ago, the clinical and genetic characteristics and survival outcomes of these patients have yet to be studied in the era of novel therapies. We retrospectively analyzed the clinicopathologic, genetic, and survival characteristics of 34 patients with confirmed tissue diagnosis of A-CLL/SLL and compared them with 120 patients with C-CLL/SLL.
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