Publications by authors named "J Albores-Saavedra"
Among malignant neoplasms, pancreatic ductal adenocarcinoma (PDAC) has one of the highest fatality rates due to its late detection. Therefore, it is essential to discover a noninvasive, early, specific, and sensitive diagnostic method. MicroRNAs (miRNAs) are attractive biomarkers because they are accessible, highly specific, and sensitive.
View Article and Find Full Text PDFPancreatic ductal adenocarcinoma (PDAC) is one of the most intractable and devastating malignant tumors. Epigenetic modifications such as DNA methylation and histone modification regulate tumor initiation and progression. However, the contribution of histone variants in PDAC is unknown.
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- This study investigates intraductal papillary mucinous neoplasms (IPMNs) and mucinous cystic neoplasms (MCNs), which are non-invasive tumors linked to pancreatic cancer, using 148 samples from 18 patients.
- It finds that both IPMNs and MCNs are direct precursors to invasive pancreatic cancer, with specific mutations occurring predominantly in malignant forms.
- The research highlights the complex genetic changes leading to pancreatic cancer and suggests a significant window for potential early detection and treatment before the disease progresses.
Atrophic carcinoma and microcystic carcinoma have previously been classified as variants of conventional acinar adenocarcinoma. In this article, we studied 4 cases of atrophic carcinoma and 4 cases of limited microcystic carcinoma. We found an incidence of 0.
View Article and Find Full Text PDFBackground: Study of minimum adenocarcinoma has been done almost exclusively on conventional acinar adenocarcinoma. Pseudohyperplastic adenocarcinoma can be confused with benign lesions because of its well-differentiated appearance and has not been studied when the biopsy shows few malignant glands (limited carcinoma).
Methods: We reviewed 94 pseudohyperplastic adenocarcinomas diagnosed in prostatic biopsies for a period of 12 years and selected those measuring less than 1 mm or involving less than 5% of the biopsied tissue.