Publications by authors named "J Al-Mutawa"

Female infertility (FI) is a global health issue. Polycystic ovary syndrome (PCOS) is a common cause of FI. The renalase gene () is associated with FI and other human diseases.

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Article Synopsis
  • Polycystic Ovarian Syndrome (PCOS) is a hormonal and metabolic disorder impacting women of reproductive age, with genetic research helping in its diagnosis and management; this study focuses on specific genetic variations related to PCOS in Saudi women.
  • The research analyzed 200 women (100 with PCOS and 100 healthy) for two specific gene SNPs using genetic testing, finding significant differences in clinical measures like age, weight, and lipid profiles between the groups.
  • Results indicated a strong association between the 1349 T > G SNP and PCOS, while the -656 T > G SNP did not show any significant impact, suggesting further exploration of genetic factors in PCOS management is warranted
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Background: Folic acid (FA) supplementation is an important intervention to avoid nutritional deficiencies during pregnancy and later on will have an effect on mother and fetus. Inadequate dietary intake will lead to nutritional deficiency which further requires to depend on supplementation. FA is one of the vital nutrients which is mandatory for improving pregnancy outcomes.

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Angiotensin-converting enzyme (ACE), a key enzyme in the renin- angiotensin-aldosterone system, converts angiotensin I to angiotensin II. Ethnic origin should be carefully considered in studies pertaining to ACE I/D genotype and disease etiology. This study was evaluated between the ACE gene I/D polymorphism and female infertility in the Saudi population.

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Background: The study meant to define the prognostic factors that help in prescribing intrauterine insemination (IUI) for infertility treatment which remains an area of continuous improvements.

Methods: The diagnostic indications of a cohort of IUI-treated patients and their corresponding pregnancy rates (PRs) were randomly and prospectively studied among Saudi cohort of 303 patients for a period of 20 months. The indications of IUI cases were statistically analyzed for those eligible patients over a period of twenty months (January 2010 till August 2011), and the PR that corresponded to each group was investigated as well.

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