The role of apoptosis in the pathogenesis of canine keratoconjunctivitis sicca: the effect of topical Cyclosporin A therapy.

Purpose: The exact etiology of dry eye is unknown but is believed to be multifactorial. Apoptosis has been implicated in the pathogenesis of autoimmune diseases such as Sjögren's syndrome (SS). This study attempted to gain a better understanding of the role of apoptosis and its regulation in the patho-physiology of dry eye.

Cyclic neutropenia in Crohn's ileocolitis: efficacy of granulocyte colony-stimulating factor.

A 40-year-old patient with long-standing Crohn's ileocolitis in remission experienced cyclic neutropenia with a periodicity of 14 days. He was not receiving immunosuppressive or myelosuppressive therapy. The patient had Staphylococcus aureus bacteremia resulting from central catheter infection, which was refractory to antibiotic therapy during the period of severe neutropenia.

Apoptosis in the rabbit cornea after photorefractive keratectomy.

Purpose: It is well-known that after trauma to the ocular surface such as that seen in refractive surgeries like photorefractive keratectomy (PRK; laser corneal surface ablation), there is a "dropout" of underlying stromal keratocytes. Recently it was proposed by Wilson et al. that this loss of keratocytes may be the result of apoptosis.