Publications by authors named "J Absil"
Objectives: Temporal lobe epilepsy (TLE) is commonly associated with mesiotemporal pathology and widespread alterations of grey and white matter structures. Evidence supports a progressive condition although the temporal evolution of TLE is poorly defined. This ENIGMA-Epilepsy study utilized multimodal magnetic resonance imaging (MRI) data to investigate structural alterations in TLE patients across the adult lifespan.
View Article and Find Full Text PDFEpilepsy is associated with genetic risk factors and cortico-subcortical network alterations, but associations between neurobiological mechanisms and macroscale connectomics remain unclear. This multisite ENIGMA-Epilepsy study examined whole-brain structural covariance networks in patients with epilepsy and related findings to postmortem epilepsy risk gene expression patterns. Brain network analysis included 578 adults with temporal lobe epilepsy (TLE), 288 adults with idiopathic generalized epilepsy (IGE), and 1328 healthy controls from 18 centres worldwide.
View Article and Find Full Text PDFArticle Synopsis
- Temporal lobe epilepsy (TLE) is mainly a limbic network disorder characterized by unilateral hippocampal issues and has been studied using structural MRI for brain grey matter changes.
- The study utilized the ENIGMA-Epilepsy dataset to compare grey matter asymmetry and atrophy in TLE patients versus healthy controls, finding distinct patterns: atypical asymmetry showed a temporo-limbic signature, while atrophy appeared diffuse and bilateral.
- Results indicated that cortical atrophy correlates with factors like disease duration and age at seizure onset, while asymmetry levels did not, suggesting that these two measures capture different but complementary aspects of TLE pathology.