Publications by authors named "J Abramson"
Objectives: Survivors of intracerebral haemorrhage (ICH) are at high risk of incident depression, which is modified by social determinants of health (SDOH) and associated with worse functional outcomes. We sought to determine the role of prestroke SDOH in depression incidence after ICH to better characterise post-ICH outcomes.
Study Design: We analysed data from a cohort study of ICH survivors without prestroke depression, presenting at Massachusetts General Hospital between 2006 and 2017.
Shake effects, resulting from sudden core potential changes during photoexcitation, are well-known in X-ray photoelectron spectroscopy (XPS) and often produce satellite peaks due to many-body excitations. It has been thought, however, that they are negligible in core-to-core X-ray emission spectroscopy (CTC-XES), where the difference in core-hole potentials upon radiative decay is rather small. We demonstrate that shake effects are significant in Kα XES from 3d transition metal systems with nominally zero valence electrons.
View Article and Find Full Text PDFBackground: Glofitamab monotherapy induces durable remission in patients with relapsed or refractory diffuse large B-cell lymphoma after two or more previous therapies, but has not previously been assessed as a second-line therapy. We investigated the efficacy and safety of glofitamab plus gemcitabine-oxaliplatin (Glofit-GemOx) versus rituximab (R)-GemOx in patients with relapsed or refractory diffuse large B-cell lymphoma.
Methods: The phase 3, randomised, open-label STARGLO trial was done at 62 centres in 13 countries in Asia and Australia, Europe, and North America.
Article Synopsis
- The voltage-dependent anion channel (VDAC) is a key protein in mitochondria that helps exchange ions and metabolites with the cytosol, and its structure was first defined in 2008.
- The recent study presents a new crystal structure of mouse VDAC-1 at room temperature, revealing differences in its loop regions compared to previous cryogenic images, which may be vital for how VDAC-1 opens and closes.
- The research suggests using electric field-stimulated X-ray crystallography (EF-X) to study the 'closed' state of VDAC-1, aiming to better understand its dynamic gating mechanism and overall role in mitochondrial functions.