Bond strength comparison of chemically activated hard reline materials on CAD-CAM milled and conventional heat-polymerized PMMA denture bases.

Statement Of Problem: Comprehensive data are needed on the performance of chemically activated, chairside hard reline materials when used with computer-aided design and computer-aided manufacturing (CAD-CAM) milled polymethyl methacrylate (PMMA) denture bases and conventionally processed bases. This lack of data affects decisions regarding the chairside reline material to be used for improving the fit and retention of relined complete dentures.

Purpose: The purpose of this in vitro study was to evaluate and compare the shear bond strength (SBS) of 3 chemically activated, chairside hard reline materials on CAD-CAM milled and conventional heat-polymerized PMMA denture bases.

Distinct Gut Microbiota Profiles in Normal Weight Obesity and Their Association With Cardiometabolic Diseases: Results From Two Independent Cohort Studies.

Background: Normal weight obesity (NWO) is characterized by excess body fat in individuals with normal body mass index (BMI). This study aimed to investigate gut microbiota alterations in NWO and their potential associations with cardiometabolic diseases (CMD) risk in two independent cohorts.

Methods: Our NWO-CMD mortality analysis included 168 099 adults with normal BMI from two large open-access databases, while our NWO-gut microbiota study involved 5467 adults with normal BMI from two independent cohorts: the WELL-China cohort and the Lanxi cohort.

Association of dietary preferences with primary ovarian insufficiency (POI): a mendelian randomization-based analysis.

Background: Primary ovarian insufficiency (POI) is a critical cause of infertility and is increasingly recognized as a complex metabolic disorder. Dietary factors may influence the risk of POI, but causal relationships remain unclear.

Methods: We conducted an MR study using genetic instrumental variables for 83 dietary preferences from the UK Biobank, with the Inverse Variance Weighted method as the primary analysis.

Metabolic shifts in lipid utilization and reciprocal interactions within the lung metastatic niche of triple-negative breast cancer revealed by spatial multi-omics.

The Triple-Negative Breast Cancer (TNBC) subtype constitutes 15-20% of breast cancer cases and is associated with the poorest clinical outcomes. Distant metastasis, particularly to the lungs, is a major contributor to the high mortality rates in breast cancer patients. Despite this, there has been a lack of comprehensive insights into the heterogeneity of metastatic tumors and their surrounding ecosystem in the lungs.

Pyridine oxide-decorated covalent organic framework for catalytic allylation of aromatic aldehydes with allyl(trichloro)silane.

A covalent organic framework Py-O-COF, which was directly synthesized from a monomer containing pyridine oxide with its partner imine condensation, could significantly promote the allylation of aromatic aldehydes with allyl(trichloro)silane in a heterogeneous manner.