Twenty-four Month Outcomes of Extended- Versus Standard-course Antibiotic Therapy in Children Hospitalized With Pneumonia in High-risk Settings: A Randomized Controlled Trial.

Background: Pediatric community-acquired pneumonia (CAP) can lead to long-term respiratory sequelae, including bronchiectasis. We determined if an extended (13-14 days) versus standard (5-6 days) antibiotic course improves long-term outcomes in children hospitalized with CAP from populations at high risk of chronic respiratory disease.

Methods: We undertook a multicenter, double-blind, superiority, randomized controlled trial involving 7 Australian, New Zealand, and Malaysian hospitals.

Antiviral strains associate with endoplasmic reticulum membranes and induce lipid droplet formation to restrict dengue virus replication.

are a genus of insect endosymbiotic bacteria which includes strains Mel and AlbB that are being utilized as a biocontrol tool to reduce the incidence of -transmitted viral diseases like dengue. However, the precise mechanisms underpinning the antiviral activity of these strains are not well defined. Here, we generated a panel of -derived cell lines infected with antiviral strains Mel and AlbB or the non-antiviral strain Pip to understand host cell morphological changes specifically induced by antiviral strains.

Morbidity and treatment costs of cystic fibrosis in a middle-income country.

Introduction: : Asian children with cystic fibrosis (CF) managed in Malaysia have significant morbidity with limited access to life-sustaining treatments. We determined the morbidity and treatment cost of CF in a resource-limited country.

Methods: This cross-sectional study included all children diagnosed with CF in our centre.

The impact of eye gaze on social interactions of females in virtual reality: The mediating role of the uncanniness of avatars and the moderating role of task type.

The introduction of the Metaverse and the rise of social virtual reality platforms such as VRChat has led to increased communication and collaboration in virtual reality. As interactions in social virtual reality take place through avatars, the behaviour, and in particular the eye gaze of an avatar can have an impact on the user experience. However, it is still unclear which features of the user experience are most influenced.