Publications by authors named "J A Zdanowicz"
Postpartum hemorrhage (PPH) is a leading cause of maternal morbidity and mortality. Routine treatment of PPH includes uterotonics, tranexamic acid, curettage, uterine (balloon) tamponade, compression sutures, uterine artery ligation, and, if available, transcatheter arterial embolization (TAE). In cases of severe PPH refractory to standard medical and surgical management, hysterectomy is usually the ultima ratio, and is equally associated with a higher rate of complications.
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- The study aimed to assess the effectiveness and safety of recombinant activated factor VIIa (rFVIIa) for treating severe postpartum hemorrhage (sPPH) through a multi-center randomized controlled trial and observational studies.
- In the RCT, a significantly lower percentage of women treated with rFVIIa required invasive procedures compared to those who did not receive the treatment, although this was not confirmed in the observational studies.
- Safety analysis revealed no increase in thromboembolic events for rFVIIa-treated women compared to non-treated women, indicating that while the efficacy may vary, the treatment is relatively safe.
Article Synopsis
- The study aimed to compare complications in monochorionic (MC) twins from spontaneously conceived (SC) and assisted reproductive technologies (ART) pregnancies over a span of 10 years in a university hospital setting.
- A total of 393 MC pregnancies were analyzed, revealing that hypothyroidism was significantly more common in ART pregnancies, along with a higher occurrence of congenital anomalies, particularly heart defects.
- Overall, while there were no major differences in chorionicity complications or neonatal outcomes, ART pregnancies showed non-significant trends toward earlier delivery and lower birth weights compared to SC pregnancies.
Postpartum hemorrhage (PPH) remains a major cause of maternal morbidity and mortality. While PPH treatment guidelines exist, data on their effect on reduction in red blood cell (RBC) transfusions and use of hemostatic products are scarce. Continuous evaluation of PPH management is important to assess potential pitfalls and incorporate new treatment options.
View Article and Find Full Text PDFHypertensive disorders of pregnancy (HDP) contribute substantially to perinatal morbidity and mortality. Epigenetic changes point towards cardio-metabolic dysregulation for these vascular disorders. In early pregnancy, epigenetic changes using cell free DNA (cfDNA) are largely unexplored.
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