Identification of serum tRNA-derived small RNAs biosignature for diagnosis of tuberculosis.

The tRNA-derived small RNAs (tsRNAs) are a new class of non coding RNAs, which are stable in body fluids and can be used as potential biomarkers for disease diagnosis. However, the exact value of tsRNAs in the diagnosis of tuberculosis (TB) is still unclear. The objective of the present study was to evaluate the performance of the serum tsRNAs biosignature to distinguish between active TB, healthy controls, latent TB infection, and other respiratory diseases.

promotes synchronous multiple primary lung cancer progression through apoptosis regulation.

Background: Dysbiosis of the lung microbiome can contribute to the initiation and progression of lung cancer. Synchronous multiple primary lung cancer (sMPLC) is an increasingly recognized subtype of lung cancer characterized by high morbidity, difficulties in early detection, poor prognosis, and substantial clinical challenges. However, the relationship between sMPLC pathogenesis and changes in the lung microbiome remains unclear.

Blood leukocyte-based clusters in patients with traumatic brain injury.

Background: Leukocytes play an important role in inflammatory response after a traumatic brain injury (TBI). We designed this study to identify TBI phenotypes by clustering blood levels of various leukocytes.

Methods: TBI patients from the Medical Information Mart for Intensive Care-III (MIMIC-III) database were included.

Integrated single-cell RNA sequencing reveals the tumor heterogeneity and microenvironment landscape during liver metastasis in adenocarcinoma of esophagogastric junction.

Background: Adenocarcinoma of the esophagogastric junction (AEGJ) is a highly aggressive tumor that frequently metastasizes to the liver. Understanding the cellular and molecular mechanisms that drive this process is essential for developing effective therapies.

Methods: We employed single-cell RNA sequencing to analyze the tumor heterogeneity and microenvironmental landscape in patients with AEGJ liver metastases.

How to implement pairing assistance during fighting COVID-19 in China: collaborative governance between local governments under the authoritative regulation.

Background: The pairing assistance policy represents a distinctive instrument utilized by the Chinese government to address major public crises. This study examines the development of a pairing assistance policy by the Chinese Government through its central authority to foster collaborative governance among local governments in areas affected by COVID-19.

Methods: The aim of the study was to gain a clear understanding of how the policy of pairing assistance in public health emergencies is successfully implemented through the top-down application of authority.