Publications by authors named "J A Wubben"
MR1 is a highly conserved microbial immune-detection system in mammals. It captures vitamin B-related metabolite antigens from diverse microbes and presents them at the cell surface to stimulate MR1-restricted lymphocytes including mucosal-associated invariant T (MAIT) cells. MR1 presentation and MAIT cell recognition mediate homeostasis through host defense and tissue repair.
View Article and Find Full Text PDFArticle Synopsis
- Mucosal-associated invariant T (MAIT) cells identify microbial infections through riboflavin-based antigens presented by MR1, a protein related to MHC-I, with most MAIT cells expressing CD8αα or CD8αβ coreceptors.
- Although the interaction between CD8 and MR1 was previously unclear, this study provides direct evidence that CD8 does engage MR1, similar to its interaction with MHC-I molecules.
- The research also reveals that both CD8αα and CD8αβ enhance MR1 binding and cytokine production in MAIT cells, indicating their role as functional coreceptors for MAIT and other MR1-reactive T cells.
SARS-CoV-2 causes acute respiratory disease, but many patients also experience neurological complications. Neuropathological changes with pronounced neuroinflammation have been described in individuals after lethal COVID-19, as well as in the CSF of hospitalized patients with neurological complications. To assess whether neuropathological changes can occur after a SARS-CoV-2 infection, leading to mild-to-moderate disease, we investigated the brains of four rhesus and four cynomolgus macaques after pulmonary disease and without overt clinical symptoms.
View Article and Find Full Text PDFMacaques are among the most commonly used non-human primates in biomedical research. They are highly social animals, yet biomedical studies often require group-living animals to be pair-housed in a controlled environment. A change in environment causes only short-term stress in adapting individuals, while non-adapting animals may experience long-term stress that can adversely affect study results.
View Article and Find Full Text PDFThe transport of host proteins into and out of the nucleus is key to host function. However, nuclear transport is restricted by nuclear pores that perforate the nuclear envelope. Protein intrinsic disorder is an inherent feature of this selective transport barrier and is also a feature of the nuclear transport receptors that facilitate the active nuclear transport of cargo, and the nuclear transport signals on the cargo itself.
View Article and Find Full Text PDF