Sexual Dimorphism of Ethanol-Induced Mitochondrial Dynamics in Purkinje Cells.

The cerebellum, a key target of ethanol's toxic effects, is associated with ataxia following alcohol consumption. However, the impact of ethanol on Purkinje cell (PC) mitochondria remains unclear. To investigate how ethanol administration affects mitochondrial dynamics in cerebellar Purkinje cells, we employed a transgenic mouse model expressing mitochondria-targeted yellow fluorescent protein in Purkinje cells (PC-mito-eYFP).

3D-printed suction clamps for tensile testing of brain tissue.

The conventional mounting of ultra-soft biological tissues often involves gluing it between two plates or manually tightening grips. Both methods demand delicate handling skills and are time-consuming. This study outlines the design and practical application of 3D-printed suction clamps for uniaxial tension tests on brain samples.

An Easily Accessible, Semi-Automated Approach to Creating Personalized Normative Feedback and Risk Feedback Graphics.

Objective: Personalized normative feedback interventions show efficacy in reducing health risk behaviors (e.g., alcohol use, sexual aggression).

Avascular necrosis or rapid destruction of the hip following hip intra-articular corticosteroid injections: a systematic review.

Purpose: This study aimed to systematically review the literature to identify the incidence of avascular necrosis (AVN) following hip intra-articular corticosteroid injections (IACSIs) as well as to elucidate risk factors that may predispose patients to AVN following IACSI.

Methods: The MEDLINE, Embase, PubMed, and Web of Science databases were systematically searched through inception to July 21, 2024, in accordance with the PRISMA statement with data extracted for descriptive analysis. The inclusion criteria were hip IACSI and AVN of the femoral head.

Simultaneous use of alcohol, cannabis, and energy drinks predicts increased daily alcohol consumption and alcohol consequences.

Simultaneous alcohol and cannabis (SAM) use and alcohol mixed with energy drinks (AmED) days are associated with heavier drinking and negative consequences compared to alcohol-only days. However, it remains unclear if SAM and AmED days differ from one another in terms of consumption and negative consequences. It also remains unclear how often days characterized by both SAM + AmED occur and if these days are associated with incremental risk for heavier drinking and negative consequences.