Publications by authors named "J A Vizcarra"
: Hyperkinetic movement disorders involve excessive, involuntary movements such as ataxia, chorea, dystonia, myoclonus, tics, and tremor. Recent advances in artificial intelligence (AI) allow investigators to integrate multimodal instrumented movement measurements and imaging techniques and to analyze these data together at scale. In this systematic review, we aim to characterize AI's performance in diagnosing and quantitatively phenotyping these disorders.
View Article and Find Full Text PDFActive ghrelin (AG) is produced through the post-translational addition of n-octanoic acid to the amino residue Ser-3, making it the natural ligand for the ghrelin receptor. The synthesis of AG is contingent upon specific dietary fatty acids as substrates for the acylation process. Prior studies have demonstrated that AG infusion can lead to reduced feed intake (FI) in broiler chickens, suggesting that manipulating AG may serve as an alternative to quantitative feed restriction in broiler breeders.
View Article and Find Full Text PDFAnimal models have been used to gain pathophysiologic insights into Parkinson's disease (PD) and aid in the translational efforts of interventions with therapeutic potential in human clinical trials. However, no disease-modifying therapy for PD has successfully emerged from model predictions. These translational disappointments warrant a reappraisal of the types of preclinical questions asked of animal models.
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- Machine learning is being used in neuropathology to improve and expand current practices, but creating large, accurately labeled imaging datasets is difficult due to the need for expert knowledge and inconsistencies among specialists.
- The study focuses on neurofibrillary tangles in Alzheimer's disease and establishes a baseline for agreement among experts on Braak NFT staging and detection, utilizing whole-slide images from Emory University Hospital.
- A new workflow is developed to efficiently label NFTs using machine learning, showing that models can learn from human annotators and predict disease progression comparably to human experts, thus providing a scalable solution for neuropathology tasks.
A 48-year-old man was referred to the movement disorders clinic for 10 years of progressive slurred speech, spasticity, limb incoordination, and wide-based gait. Extensive neurologic workup was inconclusive, including serum and CSF testing, neuroimaging, EMG/NCS, exome sequencing, and mitochondrial testing. An ataxia repeat expansion panel ultimately revealed the final diagnosis.
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