Publications by authors named "J A Vila"
: is a globally emerging pathogen with widespread antimicrobial resistance driven by multiple mechanisms, such as altered expression of efflux pumps like AdeABC, placing it as a priority for research. Driven by the lack of new treatments, alternative approaches are being explored to combat its infections, among which efficacy-enhancing adjuvants can be found. This study presents and characterizes MV6, a synthetic cyclic peptide that boosts aminoglycoside efficacy.
View Article and Find Full Text PDFPurpose: To assess the diagnostic performance of hemoglobin concentration for Meckel's diverticulum (MD) and evaluate if hemoglobin levels could be useful in the surgical decision-making process of children with lower gastrointestinal bleeding (LGIB).
Methods: Retrospective cohort study of children with LGIB attending the emergency department between 2011 and 2021. Episodes of LGIB were divided into two groups: MeckD (MD diagnosed by surgery) and non-MeckD.
potentiation of tetracyclines in by RW01, a new cyclic peptide.
Antimicrob Agents Chemother
December 2024
The pipeline for new drugs against multidrug-resistant remains limited, highlighting the urgent need for innovative treatments. New strategies, such as membrane-targeting molecules acting as adjuvants, aim to enhance antibiotic effectiveness and combat resistance. RW01, a cyclic peptide with low antimicrobial activity, was selected as an adjuvant to enhance drug efficacy through membrane permeabilization.
View Article and Find Full Text PDFSympathetic nervous system (SNS), endothelin 1 (ET-1) and angiotensin II (Ang II) are involved in the pathophysiology of acute myocardial infarction (AMI). Valproic acid (VPA) is under study for the treatment against AMI due to its beneficial cardiac effects. However, the vascular effects of VPA on the activation of the SNS, ET-1 and Ang II after AMI are not fully studied.
View Article and Find Full Text PDFAutonomic contributions to attentional modulation of the cardiac defense response.
Int J Psychophysiol
January 2025
Article Synopsis
- - The study examines how the heart's response to scary sounds involves two main components: one related to attention and the other to safety actions, showing the body's defensive response.
- - Researchers tested 60 people, measuring heart activity while some completed a visual task after hearing a scary noise, revealing that tasks increased the second heart response component and decreased blood pressure.
- - The results indicate that the initial heart response is influenced by the parasympathetic (calming) system, while both sympathetic (activating) and parasympathetic systems play roles in the second response, suggesting the task affects how we react to threats based on our attention.