Alternative splicing controls pan-neuronal homeobox gene expression.

The pan-neuronally expressed and phylogenetically conserved CUT homeobox gene orchestrates pan-neuronal gene expression throughout the nervous system of As in many other species, including humans, is encoded by a complex locus that also codes for a Golgi-localized protein, called CASP (Cux1 alternatively spliced product) in humans and CONE-1 ("CASP of nematodes") in How gene expression from this complex locus is controlled-and, in , directed to all cells of the nervous system-has not been investigated. We show here that pan-neuronal expression of CEH-44/CUX is controlled by a pan-neuronal RNA splicing factor, UNC-75, the homolog of vertebrate CELF proteins. During embryogenesis, the locus exclusively produces the Golgi-localized CONE-1/CASP protein in all tissues, but upon the onset of postmitotic terminal differentiation of neurons, UNC-75/CELF induces the production of the alternative CEH-44/CUX CUT homeobox gene-encoding transcript exclusively in the nervous system.

Avoiding Unwanted Exposure of Subperiosteal Implants in the Atrophic Maxilla: Technical Note.

The use of subperiosteal implants for the rehabilitation of atrophic maxillae has taken attention recently as a validated option in the treatment of severe atrophy. The systems have been improved by technological advancements and the analysis of variables affecting their prognosis. However, one of the most frequent issues to resolve is the unwanted exposure of a portion of the metal mesh close to the abutment and prosthetic connections, which can result in infections, hygiene problems, and, in some instances, complete failure.

A Rare Encounter of Postoperative Abscess Not Linked to Staple Line in Sleeve Gastrectomy: A Case Report and Literature Review.

Sleeve gastrectomy is a common bariatric procedure known for its safety and effectiveness, but postoperative complications like abscess formation, though rare, can occur. We report the case of a 37-year-old female who presented with atypical abdominal pain following a sleeve gastrectomy. Imaging revealed an abscess located away from the staple line.

Future changes of precipitation types in the Peruvian Andes.

In high-altitude regions, such as the Peruvian Andes, understanding the transformation of precipitation types under climate change is critical to the sustainability of water resources and the survival of glaciers. In this study, we investigate the distribution and types of precipitation on a tropical glacier in the Peruvian Central Andes. We utilized data from an optical-laser disdrometer and compact weather station installed at 4709 m ASL, combined with future climate scenarios from the CMIP6 project, to model potential future changes in precipitation types.