Publications by authors named "J A Tremmel"
Chapter 13.0. FFR, iFR, CFR, and IMR: Results from clinical trials.
Cardiovasc Revasc Med
December 2024
In this review article, we provide an overview of the definition and application of fractional flow reserve (FFR), instantaneous wave-free ratio (iFR), coronary flow reserve (CFR), and index of microvascular resistance (IMR) in the diagnosis, prognosis, and management of coronary microvascular dysfunction. We discuss their respective limitations as it relates to microvascular dysfunction. In each section, we review the most recent evidence supporting their use in microvascular and epicardial coronary artery disease.
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- * The DISCOVER INOCA registry aims to enroll 500 patients to study the prevalence of different INOCA phenotypes and their relationship with atherosclerosis over a follow-up period of five years, assessing both short-term and long-term health outcomes.
- * This study is the first to prospectively combine anatomical and physiological data to better understand INOCA and its effects on long-term cardiovascular health, potentially improving diagnosis and treatment strategies.
Article Synopsis
- Coronary microvascular dysfunction (CMD) can lead to chest pain (angina) even when there are no blockages in the major coronary arteries (ANOCA).
- The thermodilution technique is a useful method for measuring microvascular resistance, from which two key indices (coronary flow reserve and index of microcirculatory resistance) can be derived to assess coronary microcirculation.
- The text presents the bolus thermodilution method and an algorithm (CATH CMD) to standardize measurements and improve the diagnosis of CMD.
Coronary Microvascular Dysfunction.
Yader Sandoval Joaquin E Cigarroa George D Dangas Alexandra J Lansky Srihari S Naidu Jennifer A Tremmel
J Soc Cardiovasc Angiogr Interv
March 2024