Biomarkers.

Background: In older adults, greater amyloid (Aβ) and tau positron emission tomography (PET) binding is associated with cognitive decline and dementia. However, the association of early amyloid and tau PET accumulation with cognition at midlife remains unclear. The goal of the current study was to evaluate the associations of Aβ and tau PET with cognition in a predominately middle-aged community-based cohort, as well as to examine the factors that may modify these associations.

Public Health.

Background: The Apolipoprotein E (APOE) ε4 variant is the strongest genetic risk factor for Alzheimer's disease (AD) and has been thoroughly studied in non-Hispanic whites (NHW). However, its association with AD among Hispanic individuals is unclear, with existing studies yielding mixed results. Genetics do not entirely explain the likelihood of developing AD.

Biomarkers.

Background: Plasma p-tau biomarkers are promising diagnostic tools for widespread clinical use. However, recent studies have raised concerns regarding the effect of common medical comorbidities, such as cardiovascular disease (CVD), on plasma p-tau specificity. These influences must be better understood to enable appropriate clinical use of p-tau181.

Dementia Care Research and Psychosocial Factors.

Background: Globally, 47.5 million people were living with dementia in 2015. This figure is expected to reach 75.

Dementia Care Research and Psychosocial Factors.

Background: In Zambia, dementia prevalence is unknown due to limited community awareness and a lack of providers skilled in recognizing and diagnosing this disease. Community healthcare workers (CHWs) are widely utilized across sub-Saharan Africa to improve health care access, particularly HIV services. CHWs may be an untapped resource to raise awareness, screen for dementia, and support dementia care in the community.