Application of Antimicrobial Rubber-Coated Cotton Gloves for Mangosteen-Peel-Extract-Mediated Biosynthesis of Ag-ZnO Nanocomposites.

Nanocomposites based on metal nanoparticles (MNP) prepared with mangosteen () peel extract-mediated biosynthesis of Ag/Zn have attracted considerable interest due to their potential for various practical applications. In this study, their role in developing antibacterial protection for rubber cotton gloves is investigated. The process of mangosteen-peel-extract-mediated biosynthesis produced Ag/Zn nanocomposites with respective diameters of 23.

Application of comprehensive molecular genetic profiling in precision cancer medicine, Hungarian experiences.

Unlabelled: Recent developments in molecular genetic testing methods (e.g. next-generation sequencing [NGS]-panels) largely accelerated the process of finding the most appropriate targeted therapeutic intervention for cancer patients based on molecularly targetable genetic alterations.

Inflammatory and Metabolic Signaling Interfaces of the Hypertrophic and Senescent Chondrocyte Phenotypes Associated with Osteoarthritis.

Osteoarthritis (OA) is a complex disease of whole joints with progressive cartilage matrix degradation and chondrocyte transformation. The inflammatory features of OA are reflected in increased synovial levels of IL-1β, IL-6 and VEGF, higher levels of TLR-4 binding plasma proteins and increased expression of IL-15, IL-18, IL-10 and Cox2, in cartilage. Chondrocytes in OA undergo hypertrophic and senescent transition; in these states, the expression of Sox-9, Acan and Col2a1 is suppressed, whereas the expression of RunX2, HIF-2α and MMP-13 is significantly increased.

Fluconazole and echinocandin resistance of species in invasive candidiasis at a university hospital during pre-COVID-19 and the COVID-19 outbreak.

Antifungal susceptibility of species is decreasing. Successful treatment for antifungal-resistant candida infection is challenging and associated with significant mortality. We performed a prospective observational study to identify the species and antifungal susceptibilities of invasive isolates of species over a 5-year period at a university hospital in southern Thailand.