Publications by authors named "J A Stankiewicz"
Background And Objectives: Multiple sclerosis (MS) affects more than 1 million people in the United States, including reproductive-age women. There has been a paucity of prospective, pregnancy registries based on MS disease rather than medication exposures. A prospective MS pregnancy registry (PREG-MS) was established in 2017 as a prospective, single-cohort, real-world MS pregnancy registry in New England States of the United States, with goals to evaluate (1) course of MS and disease-modifying therapies (DMT) use during conception attempts and in the peripartum period, (2) pregnancy outcomes in women with MS (WwMS), and (3) longer-term developmental outcomes in offspring of WwMS.
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- The increasing accessibility of SMA treatments is leading more affected women to conceive, despite the associated risks of symptom progression during pregnancy.
- This paper discusses the case of a 21-year-old patient who received Nusinersen treatment during her third trimester, highlighting that she maintained her ability to walk even with disease progression.
- The study details both clinical outcomes, including positive postpartum motor function improvements, and economic considerations, noting no adverse effects on the patient or fetus.
Article Synopsis
- Pediatric patients with primary refractory or relapsed B-cell non-Hodgkin lymphoma (B-NHL) have a poor prognosis, as indicated by a study of 76 patients treated in Poland from 1995 to 2022.
- The 5-year overall survival probability was 76.7% and event-free survival probability was 72.9%, but outcomes worsened for those with disease progression or relapse, particularly with a 0.0% survival rate for relapsing patients.
- Key factors affecting prognosis included elevated lactate dehydrogenase, presence of B symptoms, and advanced disease at diagnosis, with hematopoietic stem cell transplantation showing potential as the most effective salvage therapy.
Article Synopsis
- SARS-CoV-2 not only infects the respiratory system but also causes gastrointestinal (GI) symptoms, leading researchers to study its GI effects in both rhesus macaques and humans.
- In macaques, infection resulted in viral RNA found in both the respiratory tract and stool, along with decreased levels of certain immune cells in the intestine, suggesting immune disturbance.
- The study highlighted the translocation of bacteria across the gut barrier during infection and noted that humans recovering from COVID-19 showed decreases in inflammatory markers, indicating a resolution of inflammation linked to GI issues.
Article Synopsis
- The study focuses on pediatric patients under 18 with non-B non-Hodgkin lymphomas (NHL), particularly rare types, examining their outcomes at a single oncology center over 20 years.
- Out of 26 children analyzed, 14 had anaplastic large cell lymphoma (ALCL), 9 had T-cell lymphoblastic lymphoma (TLL), and 3 had rare NHL types, with overall survival rates showing promising results comparable to clinical trials.
- The conclusion highlights the need for more research and dedicated clinical trials on rare NHLs to develop better treatment guidelines and strategies.