Publications by authors named "J A Simpson"

Background: Exacerbations contribute significantly to the burden of asthma. Some individuals are predisposed to recurring exacerbations however, the underlying mechanisms are not well understood.

Objective: To generate a sputum protein signature associated with future exacerbations.

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Article Synopsis
  • Primaquine is the primary medication for preventing malaria relapses but is often underused due to fears of side effects in G6PD-deficient patients.
  • A pharmacometric trial indicates that controlled doses of primaquine can be safely administered to G6PD-deficient individuals, showing promising results in Thai and Burmese volunteers.
  • The study estimates that a total primaquine dose of 5 mg/kg can be given safely over 14 days, with anticipated hemoglobin decreases that remain manageable.
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Objective: To examine airway inflammatory cell profiles in Indigenous Australian adults with asthma and chronic obstructive pulmonary disease (COPD).

Design/setting: A retrospective, cross-sectional study on data from a tertiary referral respiratory outpatient clinic.

Participants: Indigenous (n=23) and non-Indigenous (n=71) adults were matched according to diagnosis, gender and age to the ratio of 1:3.

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The purpose of this paper is to demonstrate how critical discourse analysis (CDA) frameworks can be used in cross-cultural mental health recovery research. CDA is a qualitative approach that critically appraises how language contributes to producing and reinforcing social inequalities. CDA regards linguistic productions as reflecting, consciously or unconsciously, the narrators' understandings of, or attitudes about, phenomena.

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Enhanced transport of immunomodulators via the lymphatics may increase drug exposure to therapeutic targets in the immune system. Our laboratory has demonstrated a triglyceride (TG) mimetic prodrug approach to enhance the lymphatic delivery of a model immunomodulator, mycophenolic acid (MPA), via conjugation of the carboxylic acid of MPA to a TG backbone, where the so formed prodrug is able to incorporate into intestinal TG deacylation-reacylation and lymph lipoprotein transport pathways (up to 37% of the administered dose being absorbed via the lymphatics). In the current study, another conjugation site in the molecule of MPA, i.

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