The 17-Gene Genomic Prostate Score Assay Is Prognostic for Biochemical Failure in Men With Localized Prostate Cancer After Radiation Therapy at a Community Cancer Center.

Purpose: The objective of this study was to assess the association between the Oncotype DX Genomic Prostate Score (GPS) assay and long-term outcomes in men with localized prostate cancer (PCa) after radiation therapy (RT). We hypothesized that the GPS assay is prognostic for biochemical failure (BCF), along with distant metastasis (DM) and PCa-specific mortality in patients with PCa receiving RT.

Methods And Materials: We retrospectively studied men with localized PCa treated with definitive RT at Georgia Urology from 2010 to 2016.

Protonation of Planar and Nonplanar Porphyrins: A Calorimetric and Computational Study.

Herein, we report the first calorimetric study of the protonation of planar and nonplanar free-base porphyrins: HOETPP (strongly saddled by its substituents), HT(tBu)P (strongly ruffled by its substituents), and the nominally planar porphyrins (npPs) HOEP, HTPP, HT(nPe)P, and HT(iPr)P. The observed enthalpies of protonation in solution (Δ) for formation of the dications in 1,1,2,2-tetrachloroethane with 2% trifluoroacetic acid are -45 ± 1 kcal mol for the npPs, -52.0 kcal mol for HT(tBu)P, and -70.

Metalloporphines: Dimers and Trimers.

Procedures for the purification and subsequent crystallization of the slightly soluble four-coordinate metallporphines, the simplest possible porphyrin derivatives, are described. Crystals of the porphine derivatives of cobalt(II), copper(II), platinum(II), and two polymorphs of zinc(II) were obtained. Analysis of the crystal and molecular structures shows that all except the platinum(II) derivative form an unusual trimeric species in the solid state.

A thermodynamic perspective of the metastability of holey sheets: the role of curvature.

Producing nanostructures with high surface area that are stable is important to accomplish sustained use of catalytic materials in practical settings. Avoiding the processes of ripening and sintering that typically hinder stability has long been recognized as a significant challenge and much research is focused on addressing these issues. In this article, we investigate a Pt nanostructure-a holey nanosheet-that exhibits high surface area and stability.