Angiocentric primary cutaneous T-cell-rich B-cell lymphoma: a case report and review of the literature.

Background: T-cell-rich B-cell lymphoma (TCRBCL) is an uncommon B-cell lymphoma, which is characterized histologically by a small number of neoplastic B cells surrounded by large numbers of nonneoplastic T cells. Diagnosis is frequently difficult because the neoplastic 'B-cell population may be quite sparse, and immunohistochemical and molecular analysis to identify the B-cell origin and clonality of the cells is necessary.

Methods: In this report we present an additional case of primary cutaneous TCRBCL with immunohistochemical and gene rearrangement studies and review the literature of this unusual entity.

Dysplastic nevi and the dysplastic nevus syndrome.

Patients with all the clinical features of FDNS but no family history of multiple abnormal nevi or melanoma can be compared with patients with neurofibromatosis due to a spontaneous mutation of the gene in utero. Whether or not such patients are in fact genetically identical to patients with FDNS and share their high risk of malignant melanoma remains to be determined. An isolated dysplastic nevus alone is not an adequate definition of SDNS, because current data are insufficient to show that its presence correlates with a uniquely high risk of melanoma when compared with other known risk factors.

Diminished glucose transport in Alzheimer's disease: dynamic PET studies.

Dynamic positron emission tomography with [18F]fluorodeoxyglucose was used in six patients with Alzheimer's disease (AD) and seven healthy age-matched control subjects to estimate the kinetic parameters K1*, k2*, and k3* that describe glucose transport and phosphorylation. A high-resolution tomograph was used to acquire brain uptake data in one tomographic plane, and a radial artery catheter connected to a plastic scintillator was used to acquire arterial input data. A nonlinear iterative least-squares fitting procedure that included terms for the vascular fraction and time delay to the peripheral sampling site was used to fit a three-compartment model to the brain data.

Alzheimer's disease. Age at onset and single-photon emission computed tomographic patterns of regional cerebral blood flow.

We performed this study to determine whether early- and late-onset Alzheimer's disease differ physiologically. Ten patients with a presenile (before 65 years old) onset of the disease and 16 with senile onset of the disease were evaluated clinically and neuropsychologically and studied with single photon emission computed tomography using the blood flow tracer [123I]N-isopropyl-p-iodoamphetamine. Although the presenile subjects had more severe neuropsychological abnormalities in all realms of cognitive function, including language, and showed greater reductions in regional blood flow than the older patients, they were also more severely demented, thus complicating interpretation of the results.

Mental status as a predictor of daily function in progressive dementia.

To evaluate a standardized mental status exam's ability to predict activities of daily living (ADLs), Mini Mental Status Exam (MMSE) scores and ADL scores were obtained from 59 patients with progressive dementias of widely varying severity but with no other psychiatric disorders or major medical problems. The MMSE scores explained only about one-third of the variance in both instrumental ADLs and physical ADLs in the whole sample, and the MMSE and ADLs were independent of one another in the less demented half of the sample. This suggests that cognitive losses and functional impairments are two distinct aspects of dementia severity, which must be assessed separately.