Publications by authors named "J A Schilling"

Adsorption-based processes are showing substantial potential for carbon capture. Due to the vast space of potential solid adsorbents and their influence on the process performance, the choice of the material is not trivial but requires systematic approaches. In particular, the material choice should be based on the performance of the resulting process.

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The right heart catheterization (RHC) remains an important diagnostic tool for a spectrum of cardiovascular disease processes including pulmonary hypertension (PH), shock, valvular heart disease, and unexplained dyspnea. While it gained widespread utilization after its introduction, the role of the RHC has evolved to provide valuable information for the management of advanced therapies in heart failure (HF) and cardiogenic shock (CS) to name a few. In this review, we provide a comprehensive overview on the indications, utilization, complications, interpretation, and calculations associated with RHC.

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Article Synopsis
  • Dead fungal cells, referred to as necromass, contribute significantly to long-term soil carbon pools, but the genes responsible for their decomposition are not well understood.
  • * The study focused on the fungus Trichoderma reesei and its response to low and high melanin levels in the necromass of another fungus, Hyaloscypha bicolor, revealing over 100 up-regulated genes for carbohydrate-active enzymes (CAZymes) in the presence of necromass compared to glucose.
  • * Differential expression of specific genes related to proteases and laccases was noted, particularly linked to the breakdown of melanin, offering insights into the factors affecting carbon turnover rates in this underexplored area of soil biology.
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Macitentan is a dual endothelin receptor antagonist (ERA) approved for treating pulmonary arterial hypertension (PAH). SOPRANO evaluated the efficacy and safety of macitentan versus placebo in pulmonary hypertension (PH) patients after left ventricular assist device (LVAD) implantation. SOPRANO was a phase 2, multicenter, double-blind, randomized, placebo-controlled, parallel-group study.

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  • Metabolic-dysfunction associated steatohepatitis (MASH) is linked to conditions like obesity and diabetes, leading to liver problems and cardiovascular disease, but identifying it in patients can be difficult.* -
  • Researchers developed targeted peptide radiotracers for PET imaging to visualize changes in macrophage populations in the liver of mice with MASH, observing a decrease in resident macrophages and an increase in recruited ones during disease progression.* -
  • The study found a strong correlation between the PET imaging results and tissue analysis, suggesting that these radiotracers could be useful for non-invasive diagnostics and monitoring of MASH in humans.*
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