Percent Predicted Peak Exercise Oxygen Pulse Provides Insights Into Ventricular-Vascular Response and Prognosticates HFpEF.

Background: Peak oxygen consumption and oxygen pulse along with their respective percent predicted measures are gold standards of exercise capacity. To date, no studies have investigated the relationship between percent predicted peak oxygen pulse (%PredOP) and ventricular-vascular response (VVR) and the association of %PredOP with all-cause mortality in heart failure with preserved ejection fraction (HFpEF) patients.

Objectives: The authors investigated the association between: 1) CPET measures of %PredOP and VVR; and 2) %PredOP and all-cause mortality in HFpEF patients.

Systemic Arterial Oxygen Levels Differentiate Pre- and Post-capillary Predominant Hemodynamic Abnormalities During Exercise in Undifferentiated Dyspnea on Exertion.

Background: Whether systemic oxygen levels (SaO) during exercise can provide a window into invasively derived exercise hemodynamic profiles in patients with undifferentiated dyspnea on exertion is unknown.

Methods: We performed cardiopulmonary exercise testing with invasive hemodynamic monitoring and arterial blood gas sampling in individuals referred for dyspnea on exertion. Receiver operator analysis was performed to distinguish heart failure with preserved ejection fraction from pulmonary arterial hypertension.

Exercise Blood Pressure in Heart Failure With Preserved and Reduced Ejection Fraction.

Objectives: This study aimed to evaluate hemodynamic correlates of inducible blood pressure (BP) pulsatility with exercise in heart failure with preserved ejection fraction (HFpEF), to identify relationships to outcomes, and to compare this with heart failure with reduced ejection fraction (HFrEF).

Background: In HFpEF, determinants and consequences of exercise BP pulsatility are not well understood.

Methods: We measured exercise BP in 146 patients with HFpEF who underwent invasive cardiopulmonary exercise testing.

Association of obesity-related inflammatory pathways with lung function and exercise capacity.

Background: Obesity has multifactorial effects on lung function and exercise capacity. The contributions of obesity-related inflammatory pathways to alterations in lung function remain unclear.

Research Question: To examine the association of obesity-related inflammatory pathways with pulmonary function, exercise capacity, and pulmonary-specific contributors to exercise intolerance.