Biomarkers.

Background: Alterations to the retina manifest in patients diagnosed with neurodegenerative diseases such as Alzheimer's disease (AD). Retinal imaging techniques open the possibility for non-invasive evaluation of AD pathology. Clinically AD diagnosed patients exhibit retinal amyloid deposits.

Control optimization of air traffic emissions in a two-variable dynamic model.

Since 1999, every report released by the International Panel on Climate Change has advocated a decrease in the greenhouse gas emissions associated with aviation in order to preserve the current climate. This study used a two variable differential equations model with a non-linear control term to address several aspects of the emissions stabilization issue. By optimizing the control term parameter, several management alternatives can be obtained based on the properties of the phase plane of the model solutions, as identified by a stability analysis.

Pharmacogenetics of Neoadjuvant MAP Chemotherapy in Localized Osteosarcoma: A Study Based on Data from the GEIS-33 Protocol.

Osteosarcoma is a rare disease, but it is the most frequent malignant bone tumor. Primary treatment consists of preoperative MAP (methotrexate (MTX), doxorubicin and cisplatin) chemotherapy followed by surgery and adjuvant chemotherapy. Pathological response to preoperative chemotherapy is one of the most important prognostic factors, but molecular biomarkers are lacking.

Genetic Diversity and Relationships Among Tunisian Wild and Cultivated L. Species.

Assessing and determining genetic diversity in rose species is a crucial step for conservation efforts, the establishment of a core collection, and the development of new varieties. This study represents the first investigation of genetic diversity among various rose species at different ploidy levels in Tunisia, with the aim of elucidating the genetic structure of the genus. It encompasses both spontaneous and cultivated accessions, featuring local and introduced species recognized for their adaptability, ornamental value, and fragrance.

Characteristics of pulmonary rehabilitation programs and their effects on exercise capacity and health related quality of life (HRQoL) in patients with interstitial lung disease: A systematic review and meta-analysis.

Background: Interstitial Lung Disease (ILD) is characterized by dyspnoea, reduced exercise capacity and poor health related quality of life (HRQoL). The evidence to support the benefits of pulmonary rehabilitation (PR) on exercise capacity (EC) and HRQoL in this population is still limited. We aimed to determine the effect of the different PR components on exercise capacity and HRQoL in patients with ILD.