Publications by authors named "J A Sabo"
Purpose: During COVID-19, significant changes in protein abundance can be linked with disease-related processes. The mass spectrometry-based proteomics of COVID-19-related biomarkers can help with the prognosis and diagnosis of this severe disease.
Design: Here, we surveyed scientific works in terms of proteomic analysis of solid tissues and non-blood fluids from COVID-19 patients.
Article Synopsis
- - MICAL proteins are essential for controlling actin filaments in cells, affecting important processes such as cell shape, division, and nerve growth, but their activity needs careful regulation to avoid harmful changes in cell structure.
- - Previous research hinted that MICAL proteins are kept inactive (autoinhibited) and need specific proteins (Rab proteins) to activate, but the exact details weren't clear until now.
- - The study unveils the structure of MICAL1, revealing how its activation relies on internal interactions within the protein and connections with other protein domains, highlighting a similar mechanism across different MICAL proteins.
Microtubule (MT) and F-actin cytoskeletal cross-talk and organization are important aspects of axon guidance mechanisms, but how associated proteins facilitate this function remains largely unknown. While the MT-associated protein, CKAP5 (XMAP215/ch-TOG), has been best characterized as a MT polymerase, we have recently highlighted a novel role for CKAP5 in facilitating interactions between MT and F-actin and in embryonic neuronal growth cones. However, the mechanism by which it does so is unclear.
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- * Asciminib is being studied in the ASC2ESCALATE trial, a Phase II study aiming to evaluate its effectiveness and safety as a second-line treatment for CML-CP after failure of one previous tyrosine kinase inhibitor (TKI).
- * The main goal of the trial is to achieve a major molecular response at 12 months, with additional focuses on molecular responses and overall survival.
1,4-Dioxane is a probable human carcinogen and a persistent aquatic contaminant. Cometabolic biodegradation of 1,4-dioxane is a promising low-cost and effective treatment technology; however, further demonstration is needed for treating landfill leachate. This technology was tested in two full-scale moving bed biofilm reactors (MBBRs) treating raw landfill leachate with tetrahydrofuran selected as the cometabolite.
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