Publications by authors named "J A S Barber"
Spectroscopy-guided isolation of extracts of the Tongan marine sponge cf. (Lamarck, 1814) has resulted in the reisolation of the labdane diterpenoid luakuliide A () and one new congener, luakulialactam A (). In addition to establishing the absolute configuration of , synthetic modifications to the luakuliide framework at key positions has created a set of six derivatives (-) which were used to interrogate a structure-activity relationship relating to the immunomodulatory effects of luakuliide A.
View Article and Find Full Text PDFIntroduction: Paediatric fractures are common but can be easily missed on radiography leading to potentially serious implications including long-term pain, disability and missed opportunities for safeguarding in cases of inflicted injury. Artificial intelligence (AI) tools to assist fracture detection in adult patients exist, although their efficacy in children is less well known. This study aims to evaluate whether a commercially available AI tool (certified for paediatric use) improves healthcare professionals (HCPs) detection of fractures, and how this may impact patient care in a retrospective simulated study design.
View Article and Find Full Text PDFArticle Synopsis
- - The study evaluated the quality of cognitive-behavioral therapy (CBT) delivered by therapists to patients with depression and anxiety in routine psychiatric care, focusing on adherence, competence, and therapy effectiveness.
- - A total of 85 patients and 29 therapists were involved, with therapist adherence rated differently by patients, therapists, and observers, while most therapists demonstrated competence in CBT according to a standardized assessment.
- - Despite high therapist adherence and competence, there was no association found between these factors and patient outcomes, indicating that CBT delivered in routine settings was effective, similar to results in controlled studies.
Spectrum of neuropsychological challenges in Turner syndrome.
Front Endocrinol (Lausanne)
December 2024
Article Synopsis
- Turner syndrome (TS) presents neuropsychological challenges that warrant formal assessments at critical developmental stages.
- A study reviewed neuropsychological assessments from patients diagnosed with TS between January 2019 and October 2022, focusing on their karyotype differences.
- Results showed that patients with a 45,X karyotype had lower median IQ scores, and common diagnoses included ADHD, anxiety disorders, learning difficulties, and autism, highlighting the need for early and regular neuropsychological testing for individuals with TS.