Publications by authors named "J A Ryals"
Chronic pain is a substantial health burden and options for treating chronic pain remain minimally effective. Ketogenic diets are emerging as well-tolerated, effective therapeutic strategies in preclinical models of chronic pain, especially diabetic neuropathy. We tested whether a ketogenic diet is antinociceptive through ketone oxidation and related activation of ATP-gated potassium (K) channels in mice.
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- Chronic pain is a significant health issue with limited treatment options, and ketogenic diets are showing promise as effective therapies in preclinical studies, particularly for conditions like diabetic neuropathy.
- A study on mice revealed that a week on a ketogenic diet led to reduced pain responses to various painful stimuli and decreased signs of neuronal activation in the spinal cord.
- The research indicates that the pain-relieving effects of the ketogenic diet may rely on ketone oxidation in sensory neurons and the activation of ATP-gated potassium channels, suggesting these channels could be a new target for pain relief.
Ketogenic diets are emerging as protective interventions in preclinical and clinical models of somatosensory nervous system disorders. Additionally, dysregulation of succinyl-CoA 3-oxoacid CoA-transferase 1 (SCOT, encoded by Oxct1), the fate-committing enzyme in mitochondrial ketolysis, has recently been described in Friedreich's ataxia and amyotrophic lateral sclerosis. However, the contribution of ketone metabolism in the normal development and function of the somatosensory nervous system remains poorly characterized.
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- Ketogenic diets show promise as protective treatments for nerve disorders, with specific focus on conditions like Friedreich's ataxia and amyotrophic lateral sclerosis that involve impaired ketone metabolism.
- Researchers created a specialized mouse model lacking the SCOT enzyme in sensory neurons to investigate the impacts of ketone metabolism on the somatosensory system’s structure and function.
- Findings indicated that the knockout mice had significant issues, such as myelination deficits and proprioceptive problems, highlighting the critical role of ketone metabolism in the normal development of the somatosensory nervous system and potential links to neurological symptoms in certain disorders.
Medical abzymology has made a great contribution to the development of general autoimmunity theory: it has put the autoantibodies (Ab) as the key brick of the theory to the level of physiological functionality by providing such Ab with the ability to catalyze and mediate direct and independent cytotoxic effect on cellular and molecular targets. Natural catalytic autoantibodies (abzymes) while being a pool of canonical Abs and possessing catalytic activity belong to the new group of physiologically active substances whose features and properties are evolutionary consolidated in one functionally active biomolecule. Therefore, further studies on Ab-mediated autoAg degradation and other targeted Ab-mediated proteolysis may provide biomarkers of newer generations and thus a supplementary tool for assessing the disease progression and predicting disability of the patients and persons at risks.
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