Publications by authors named "J A Rowlands"
Annually, tens of thousands of U.S. children and adolescents are hospitalized with seasonal influenza virus infection.
View Article and Find Full Text PDFRisk of Clade II Mpox Associated with Intimate and Nonintimate Close Contact Among Men Who Have Sex with Men and Transgender Adults - United States, August 2022-July 2023.
MMWR Morb Mortal Wkly Rep
October 2024
Article Synopsis
- A global outbreak of clade II mpox has been primarily affecting gay, bisexual, and other men who have sex with men (MSM) since May 2022, with limited understanding of transmission routes.
- A study analyzed 457 case-patients and 1,030 control patients (aged 18-49) to estimate the odds of mpox transmission based on different types of close contact; results showed that those engaging in condomless receptive anal sex had a 5.4 times higher odds of contracting mpox.
- Despite the effectiveness of the mpox vaccine, vaccination rates are low, highlighting the need for a comprehensive prevention strategy that includes vaccination promotion and safer sex practices.
Background: A U.S. case-control study (2010-2014) demonstrated vaccine effectiveness (VE) for ≥ 1 dose of the thirteen-valent pneumococcal conjugate vaccine (PCV13) against vaccine-type (VT) invasive pneumococcal disease (IPD) at 86 %; however, it lacked statistical power to examine VE by number of doses and against individual serotypes.
View Article and Find Full Text PDFVPS35 and retromer dysfunction in Parkinson's disease.
Philos Trans R Soc Lond B Biol Sci
April 2024
The () gene encodes a core component of the retromer complex essential for the endosomal sorting and recycling of transmembrane cargo. Endo-lysosomal pathway deficits are suggested to play a role in the pathogenesis of neurodegenerative diseases, including Parkinson's disease (PD). Mutations in cause a late-onset, autosomal dominant form of PD, with a single missense mutation (D620N) shown to segregate with disease in PD families.
View Article and Find Full Text PDFArticle Synopsis
- Over 30,000 monkeypox cases were reported in the U.S. by March 31, 2023, with the outbreak mainly affecting gay, bisexual, and transgender individuals.
- The FDA approved the JYNNEOS vaccine in 2019 for smallpox and monkeypox prevention, and in August 2022, allowed a new injection method to increase vaccine access.
- A study showed that JYNNEOS vaccine effectiveness was 75.2% for partial vaccination and 85.9% for full vaccination among men who have sex with men and transgender individuals aged 18-49.