Publications by authors named "J A Rowell"
Article Synopsis
- Researchers studied the TCRβ and TCRα chain sequences in different thymocyte populations from mouse fetuses and young adults to understand how life-stage affects TCR gene usage.
- They found that the foetal thymocyte populations showed a preference for particular gene segments, exhibiting less diversity and more clonotypic expansions compared to adults, indicating distinct developmental characteristics.
- Interestingly, when young adult thymocytes were treated to synchronize differentiation, they displayed more foetal-like gene usage patterns, suggesting that developmental influences can be manipulated.
Synthesis of high-entropy oxide (HEO) nanocrystals has focused on increasing the temperature in the entropy term ((Δ)) to overcome the enthalpy term. However, these high temperatures lead to large, polydisperse nanocrystals. In this work, we leverage the low solubility product () of metal oxides and optimize the Lewis-acid-catalyzed esterification reaction for equal rate production of the cation monomers to synthesize HEO nanocrystals at low temperatures, producing the smallest (<4 nm) and most monodisperse (<15% size dispersity) HEOs to date.
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- Measuring 3D chemical distribution in nanoscale materials has been challenging due to the rarity of inelastic scattering events, which require high beam exposure that can damage samples.
- High-resolution 3D chemical imaging was successfully achieved at nearly one-nanometer resolution in various nanomaterials using a method called fused multi-modal electron tomography.
- This technique significantly reduces radiation exposure by up to 99% by combining data from elastic and inelastic signals, allowing for accurate chemical mapping in complex materials.
Background: Increasing frequency of intermittent oral corticosteroid (OCS) prescription and cumulative OCS exposure increase the risk of OCS-related adverse outcomes.
Objective: We sought to describe the evolution and trajectory of intermittent OCS prescription patterns in patients with asthma and investigate risk factors independently associated with transitioning to a frequent prescription pattern.
Methods: This historical cohort study included patients with active asthma managed in UK primary care and included in the Optimum Patient Care Research Database (OPCRD; opcrd.