Delivery systems for astaxanthin: A review on approaches for in situ dosage in the treatment of inflammation associated diseases.

Astaxanthin is a red-orange keto-carotenoid exhibiting antioxidant activity. AST is mainly used in the cosmetic, food, and healthcare industries. Nevertheless, because of its anti-inflammatory effects and immune modulation activity, AST use in pharmacology has been proposed as an alternative for treating neurodegenerative disorders, inflammatory bowel disease, arthritis, atherosclerosis, or diabetic foot ulcers, among others.

Mending a broken heart by biomimetic 3D printed natural biomaterial-based cardiac patches: a review.

Myocardial infarction is one of the major causes of mortality as well as morbidity around the world. Currently available treatment options face a number of drawbacks, hence cardiac tissue engineering, which aims to bioengineer functional cardiac tissue, for application in tissue repair, patient specific drug screening and disease modeling, is being explored as a viable alternative. To achieve this, an appropriate combination of cells, biomimetic scaffolds mimicking the structure and function of the native tissue, and signals, is necessary.

Correction: 45S5 bioactive glass-based scaffolds coated with cellulose nanowhiskers for bone tissue engineering.

[This corrects the article DOI: 10.1039/C4RA07740G.].

Bioactive Glass Applications: A Literature Review of Human Clinical Trials.

The use of bioactive glasses in dentistry, reconstructive surgery, and in the treatment of infections can be considered broadly beneficial based on the emerging literature about the potential bioactivity and biocompatibility of these materials, particularly with reference to Bioglass 45S5, BonAlive and 19-93B3 bioactive glasses. Several investigations have been performed (i) to obtain bioactive glasses in different forms, such as bulk materials, powders, composites, and porous scaffolds and (ii) to investigate their possible applications in the biomedical field. Although in vivo studies in animals provide us with an initial insight into the biological performance of these systems and represent an unavoidable phase to be performed before clinical trials, only clinical studies can demonstrate the behavior of these materials in the complex physiological human environment.

An organic-inorganic hybrid scaffold with honeycomb-like structures enabled by one-step self-assembly-driven electrospinning.

Electrospun organic/inorganic hybrid scaffolds have been appealing in tissue regeneration owing to the integrated physicochemical and biological performances. However, the conventional electrospun scaffolds with non-woven structures usually failed to enable deep cell infiltration due to the densely stacked layers among the fibers. Herein, through self-assembly-driven electrospinning, a polyhydroxybutyrate/poly(ε-caprolactone)/58S sol-gel bioactive glass (PHB/PCL/58S) hybrid scaffold with honeycomb-like structures was prepared by manipulating the solution composition and concentration during a one-step electrospinning process.