Publications by authors named "J A Raleigh"
Objective: To describe the clinical characteristics, treatments, complications, and outcomes in dogs with nasal planum squamous cell carcinoma (SCC) undergoing local treatment.
Methods: A retrospective, multi-institutional study was performed. Medical records were searched to identify dogs diagnosed with nasal planum SCC.
Droplet digital PCR (ddPCR) has been demonstrated in many research studies to be a sensitive method in the analysis of circulating tumour DNA (ctDNA) for identifying mutations and tracking disease. The transition of ddPCR into the diagnostic setting requires a number of critical steps including the assessment of accuracy and precision and ultimately implementation into clinical use. Here we present the clinical validation of ddPCR for the detection of BRAF mutations (V600E and V600K) from plasma.
View Article and Find Full Text PDFObjective: To describe the clinical characteristics, perioperative protocols, and outcomes in dogs diagnosed with ventricular fibrillation (VF) while undergoing pericardiectomy.
Study Design: Retrospective, multi-institutional study.
Animals: Sixteen client-owned dogs.
Article Synopsis
- * Using advanced sequencing and digital PCR techniques, researchers found that cfmDNA concentrations were low but significantly higher than in control samples, revealing the presence of gut bacteria.
- * The findings emphasize the need for rigorous contamination controls in microbiome studies and propose a decontamination framework for accurate detection of cfmDNA in cancer research.
Article Synopsis
- The study investigates the link between the Sarcopenia Index (SI), a measure of skeletal muscle mass, and clinical outcomes in elderly patients undergoing transcatheter aortic valve replacement (TAVR).
- The results showed that a lower SI was associated with higher rates of mortality and readmissions for congestive heart failure within one year after the procedure.
- Findings suggest that the Sarcopenia Index could serve as an important predictor for adverse outcomes in TAVR patients, highlighting the significance of muscle mass in their recovery.