Publications by authors named "J A RITTER"
Tendon Transfer Procedures for Correction of Foot Drop Due to Injury to the Peripheral Nerves or Muscles.
J Brachial Plex Peripher Nerve Inj
January 2025
Foot drop is a challenging condition that significantly impacts the affected patient's mobility and quality of life. Tendon transfer has emerged as a viable treatment option. We hereby present data of the tendon transfer procedures in patients with foot drop in our department.
View Article and Find Full Text PDFThe global spread of the highly pathogenic avian influenza (HPAI) A(H5N1) virus poses a serious pandemic threat, necessitating the swift development of effective vaccines. The success of messenger RNA (mRNA) vaccine technology in the COVID-19 pandemic, marked by its rapid development and scalability, demonstrates its potential for addressing other infectious threats, such as HPAI A(H5N1). We therefore evaluated mRNA vaccine candidates targeting panzootic influenza A(H5) clade 2.
View Article and Find Full Text PDFArticle Synopsis
- - CRISPR-engineered CAR T cells show promise in cancer treatments but have been linked to chromosomal issues due to the CRISPR process.
- - The study reveals that increased T cell activation and faster proliferation lead to larger DNA deletions, while non-activated T cells have a lower risk but are less effective for gene editing.
- - A small molecule called pifithrin-α can reduce chromosomal damage while preserving the functionality of CRISPR-engineered T cells, making it a viable strategy for improving genomic safety.
Article Synopsis
- - Bartonella quintana can lead to serious health issues, including endocarditis and chronic infections, and is mainly spread by body lice, particularly in homeless populations.
- - A case study in the U.S. highlighted two kidney transplant recipients who contracted the infection from an organ donor who was homeless; one case was atypical while the other showed mild symptoms.
- - Timely detection and treatment allowed both recipients to recover, emphasizing the importance of assessing organ donors' living conditions, specifically those with a history of homelessness or lice infestations, for potential B. quintana infections in transplant recipients.
Article Synopsis
- Carriers of BRCA1/2 pathogenic variants were studied to determine their risk of developing cancers during childhood, adolescence, and young adulthood (CAYA).
- Analysis of data from over 47,000 individuals revealed that while young women with BRCA1/2 mutations had a significantly increased risk of breast cancer in their 20s, no increased risk was found for other types of CAYA cancers.
- The study concluded that there's little evidence to support routine genetic testing for children of BRCA1/2 carriers or for young cancer patients, as the overall cancer risk appears low aside from breast cancer in young women.