Comparison of the effectiveness of awake-prone positioning and high-flow nasal oxygen in patients with COVID-19-related acute respiratory failure between different waves.

Objective: To compare the effectiveness of the awake-prone position on relevant clinical outcomes in patients with COVID-19-related acute respiratory failure requiring high-flow nasal oxygen between different waves in Argentina.

Methods: This multicenter, prospective cohort study included adult patients with COVID-19-related acute respiratory failure requiring high-flow nasal oxygen. The main exposure position was the awake-prone position (≥ 6 hours/day) compared to the non-prone position.

Localized In Vivo Prodrug Activation Using Radionuclides.

Radionuclides used for imaging and therapy can show high molecular specificity in the body with appropriate targeting ligands. We hypothesized that local energy delivered by molecularly targeted radionuclides could chemically activate prodrugs at disease sites while avoiding activation in off-target sites of toxicity. As proof of principle, we tested whether this strategy of radionuclide-induced drug engagement for release (RAiDER) could locally deliver combined radiation and chemotherapy to maximize tumor cytotoxicity while minimizing off-target exposure to activated chemotherapy.

High interest for long-acting injectable PrEP among men who have sex with men at most risk for HIV in San Francisco, 2021.

Background Men who have sex with men (MSM) represent a disproportionate total of incident HIV cases. Oral pre-exposure prophylaxis (PrEP) has contributed to significant declines in total HIV incidence. Barriers to PrEP include individual and structural factors that can prevent PrEP adherence and persistence.

A Protocol for Adapting a Mindfulness-Based Intervention with Contingency Management to Reduce Alcohol Misuse Among Latine Emerging Adults.

Emerging adulthood (ages 18-25 years old) is a critical period for the onset of problematic drinking, especially within underserved populations, such as Latine emerging adults. This protocol outlines the adaptation of a Mindfulness-Based Intervention (MBI) incorporating Contingency Management (CM) to address alcohol misuse in Latine young adults, a demographic with limited treatment access and increased vulnerability to substance use disorders. Grounded in Community-Engaged Research (CEnR) principles, this study employs a structured formative development approach to culturally and developmentally adapt a Mindfulness-Based Stress Reduction (MBSR) program.