Publications by authors named "J A Prazich"
Article Synopsis
- Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder that impacts motor neurons and can vary in age of onset, progression rate, and symptoms.
- ALS4, a subtype of ALS caused by mutations in the senataxin gene, typically presents in younger patients and progresses slowly, leading to mobility issues in their fifties.
- Research using mouse models has revealed a unique immune response involving CD8 T cells in ALS4 that may help to understand disease mechanisms and could serve as a possible biomarker for tracking the disease.
The technique for measuring platelet aggregate ratios described by Wu and Hoak (1974) was evaluated in normal subjects. The following had no influence upon the test result: age, sex, fasting versu the postprandial state, and the degree of stasis prior to drawing the sample. Variance within subjects was small compared to variance between subjects (0.
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