Publications by authors named "J A Pezuk"
Article Synopsis
- Childhood cancer, though rare, leads to significant mortality, with a child dying from cancer every 3 minutes globally, highlighting the need for better treatment options.
- The study focuses on analyzing kinase functionality in pediatric solid tumors, exploring their expression patterns and correlation with clinical outcomes, as well as investigating the effectiveness of kinase inhibitors.
- A review of small molecules targeting kinases and their potential clinical applications is provided, while addressing challenges such as lack of specific compounds for childhood cancers and issues with resistance.
Article Synopsis
- * A comprehensive review and data analysis from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) confirmed varying expression levels of miR-708 in different tumors, highlighting its dual profile as some tumors showed high expression while others had low.
- * Investigation of miR-708's targets revealed 572 genes involved in crucial pathways like PI3K-Akt and p53 signaling, showcasing it as a potential diagnostic marker, but its therapeutic application is limited due to complex functions and
MicroRNAs are small RNA molecules that regulate gene expression in cells. These small molecules comprise 17 to 25 nucleotides and are able to recognize target messenger RNAs by sequence complementarity and regulate their protein translation. Different microRNAs are expressed in all human cells.
View Article and Find Full Text PDFGlioblastomas (GBMs), the most common and lethal primary brain tumor, show inherent infiltrative nature and high molecular heterogeneity that make complete surgical resection unfeasible and unresponsive to conventional adjuvant therapy. Due to their fast growth rate even under hypoxic and acidic conditions, GBM cells can conserve the intracellular pH at physiological range by overexpressing membrane-bound carbonic anhydrases (CAs). The synthetic sulfonamide E7070 is a potent inhibitor of CAs that harbors putative anticancer properties; however, this drug has still not been tested in GBMs.
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